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    Ostf1 osteoclast stimulating factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 20409, updated on 17-Aug-2024

    Summary

    Official Symbol
    Ostf1provided by MGI
    Official Full Name
    osteoclast stimulating factor 1provided by MGI
    Primary source
    MGI:MGI:700012
    See related
    Ensembl:ENSMUSG00000024725 AllianceGenome:MGI:700012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SH3P2; Sh3d3
    Summary
    Enables SH3 domain binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; peripheral nervous system ganglion; sensory organ; and urinary system. Orthologous to human OSTF1 (osteoclast stimulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 31.9), adrenal adult (RPKM 21.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Ostf1 in Genome Data Viewer
    Location:
    19 B; 19 13.17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (18557728..18609177, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (18580364..18631813, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45685 Neighboring gene ribosomal protein L29, pseudogene 6 Neighboring gene STARR-positive B cell enhancer ABC_E7637 Neighboring gene STARR-positive B cell enhancer ABC_E9992 Neighboring gene nicotinamide riboside kinase 1 Neighboring gene carnosine N-methyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    osteoclast-stimulating factor 1
    Names
    SH3 domain protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017375.3NP_059071.1  osteoclast-stimulating factor 1

      See identical proteins and their annotated locations for NP_059071.1

      Status: VALIDATED

      Source sequence(s)
      AK002899, AK145949, BY065904
      Consensus CDS
      CCDS37930.1
      UniProtKB/Swiss-Prot
      Q3UF05, Q62422
      UniProtKB/TrEMBL
      A0A494BA97
      Related
      ENSMUSP00000025631.7, ENSMUST00000025631.7
      Conserved Domains (3) summary
      cd11772
      Location:1668
      SH3_OSTF1; Src Homology 3 domain of metazoan osteoclast stimulating factor 1
      cd00204
      Location:75189
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:76103
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      18557728..18609177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)