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    Itsn2 intersectin 2 [ Mus musculus (house mouse) ]

    Gene ID: 20403, updated on 25-Aug-2018

    Summary

    Official Symbol
    Itsn2provided by MGI
    Official Full Name
    intersectin 2provided by MGI
    Primary source
    MGI:MGI:1338049
    See related
    Ensembl:ENSMUSG00000020640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ese2; Sh3d1B; Sh3p18; AI327390; mKIAA1256
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.2), spleen adult (RPKM 6.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Itsn2 in Genome Data Viewer
    Location:
    12; 12 A1.1
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (4592467..4713952)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (4599814..4720758)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31938 Neighboring gene predicted gene, 46332 Neighboring gene predicted gene, 40835 Neighboring gene ribosomal protein L18A pseudogene Neighboring gene family with sequence similarity 228, member A Neighboring gene family with sequence similarity 228, member B Neighboring gene profilin family, member 4 Neighboring gene tubulin, alpha 1C pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rho guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    intersectin-2
    Names
    EH and SH3 domains protein 2
    EH domain and SH3 domain regulator of endocytosis 2
    Eh domain, SH3 domain regulator of endocytosis 2
    SH3 domain protein 1B
    SH3 domain-containing protein 1B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198968.2NP_001185897.1  intersectin-2 isoform 1

      See identical proteins and their annotated locations for NP_001185897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC241534, BC037119, BC138262
      UniProtKB/TrEMBL
      B2RR82
      Related
      ENSMUSP00000151896.1, ENSMUST00000220311.1
      Conserved Domains (15) summary
      cd08375
      Location:15431677
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:747803
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:883934
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9731024
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10451103
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11181171
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14081540
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:12021382
      RhoGEF; RhoGEF domain
      pfam13499
      Location:250307
      EF-hand_7; EF-hand domain pair
      pfam16617
      Location:806883
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl01868
      Location:663735
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl19219
      Location:521614
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:343429
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001198969.2NP_001185898.1  intersectin-2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' exons and has a novel 3' terminus, compared to variant 1. It encodes an isoform (3) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC241534, AK031390, BC138262
      UniProtKB/TrEMBL
      B2RR82, Q8CD59
      Conserved Domains (5) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam13499
      Location:250307
      EF-hand_7; EF-hand domain pair
      cl19219
      Location:521614
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:343429
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. NM_011365.4NP_035495.2  intersectin-2 isoform 2

      See identical proteins and their annotated locations for NP_035495.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame alternate exon in the 5' coding region, compared to variant 1, which results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC241534, BC037119, BC138262
      Consensus CDS
      CCDS36398.1
      UniProtKB/TrEMBL
      B2RR82, E9QNG1
      Related
      ENSMUSP00000052758.7, ENSMUST00000062580.7
      Conserved Domains (16) summary
      cd08375
      Location:15161650
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:720776
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:856907
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:946997
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10181076
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10911144
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:13811513
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:11751355
      RhoGEF; RhoGEF domain
      pfam13499
      Location:250307
      EF-hand_7; EF-hand domain pair
      pfam15619
      Location:537705
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16617
      Location:779856
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl01868
      Location:619708
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl19219
      Location:521614
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:343429
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      4592467..4713952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515024.3XP_006515087.1  intersectin-2 isoform X1

      See identical proteins and their annotated locations for XP_006515087.1

      UniProtKB/TrEMBL
      B2RR82
      Conserved Domains (15) summary
      cd08375
      Location:15431677
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:747803
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:883934
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9731024
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10451103
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11181171
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14081540
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:12021382
      RhoGEF; RhoGEF domain
      pfam13499
      Location:250307
      EF-hand_7; EF-hand domain pair
      pfam16617
      Location:806883
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl01868
      Location:663735
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl19219
      Location:521614
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:343429
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006515026.3XP_006515089.1  intersectin-2 isoform X3

      Conserved Domains (12) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:747803
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:883934
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9731024
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10451103
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11181171
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam13499
      Location:250307
      EF-hand_7; EF-hand domain pair
      pfam16617
      Location:806883
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl01868
      Location:663735
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl19219
      Location:521614
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:343429
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. XM_006515027.3XP_006515090.1  intersectin-2 isoform X4

      Conserved Domains (13) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:720776
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:856907
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:946997
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10181076
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10911144
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam13499
      Location:250307
      EF-hand_7; EF-hand domain pair
      pfam15619
      Location:537705
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16617
      Location:779856
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl01868
      Location:619708
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl19219
      Location:521614
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:343429
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. XM_006515023.3XP_006515086.1  intersectin-2 isoform X1

      See identical proteins and their annotated locations for XP_006515086.1

      UniProtKB/TrEMBL
      B2RR82
      Conserved Domains (15) summary
      cd08375
      Location:15431677
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:747803
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:883934
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9731024
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10451103
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11181171
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:249315
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:14081540
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:12021382
      RhoGEF; RhoGEF domain
      pfam13499
      Location:250307
      EF-hand_7; EF-hand domain pair
      pfam16617
      Location:806883
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl01868
      Location:663735
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl19219
      Location:521614
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:343429
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. XM_006515025.3XP_006515088.1  intersectin-2 isoform X2

      Conserved Domains (15) summary
      cd08375
      Location:15291663
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:733789
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:869920
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9591010
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10311089
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11041157
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:235301
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:13941526
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00621
      Location:11881368
      RhoGEF; RhoGEF domain
      pfam13499
      Location:236293
      EF-hand_7; EF-hand domain pair
      pfam16617
      Location:792869
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl01868
      Location:649721
      YukC; WXG100 protein secretion system (Wss), protein YukC
      cl19219
      Location:507600
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:329415
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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