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    Srsf5 serine/arginine-rich splicing factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 20384, updated on 2-Oct-2018

    Summary

    Official Symbol
    Srsf5provided by MGI
    Official Full Name
    serine/arginine-rich splicing factor 5provided by MGI
    Primary source
    MGI:MGI:98287
    See related
    Ensembl:ENSMUSG00000021134 Vega:OTTMUSG00000021161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfrs5
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Nov 2016]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 229.5), bladder adult (RPKM 197.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Srsf5 in Genome Data Viewer
    Location:
    12; 12 C3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (80945504..80950507)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (82046491..82051494)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700052I22 gene Neighboring gene predicted gene, 20337 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 1 Neighboring gene SPARC related modular calcium binding 1 Neighboring gene ribosomal protein S8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC96781

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RS domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 5
    Names
    delayed-early protein HRS
    pre-mRNA-splicing factor SRP40
    splicing factor, arginine/serine-rich 5 (SRp40, HRS)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079694.2NP_001073162.1  serine/arginine-rich splicing factor 5 isoform 1

      See identical proteins and their annotated locations for NP_001073162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AA388848, AC125092, AK146624, BC082593
      Consensus CDS
      CCDS36484.1
      UniProtKB/Swiss-Prot
      O35326
      Related
      ENSMUSP00000131323.1, ENSMUST00000094693.10
      Conserved Domains (2) summary
      cd12337
      Location:571
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:108178
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    2. NM_001079695.2NP_001073163.1  serine/arginine-rich splicing factor 5 isoform 1

      See identical proteins and their annotated locations for NP_001073163.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AA388848, AC125092, AK146624, BY143979
      Consensus CDS
      CCDS36484.1
      UniProtKB/Swiss-Prot
      O35326
      Related
      ENSMUSP00000105985.2, OTTMUSP00000023359, ENSMUST00000110356.2, OTTMUST00000050126
      Conserved Domains (2) summary
      cd12337
      Location:571
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:108178
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    3. NM_001347415.1NP_001334344.1  serine/arginine-rich splicing factor 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1. Variants 4 and 5 encode the same isoform (2).
      Source sequence(s)
      AA388848, AC125092, AK007729, BE989777, BY634333
      Consensus CDS
      CCDS83974.1
      UniProtKB/TrEMBL
      Q9D8S5
      Conserved Domains (2) summary
      cd12337
      Location:571
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:108178
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    4. NM_001347416.1NP_001334345.1  serine/arginine-rich splicing factor 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1. Variants 4 and 5 encode the same isoform (2).
      Source sequence(s)
      AA388848, AC125092, AK007729, AK146624, BY634333
      Consensus CDS
      CCDS83974.1
      UniProtKB/Swiss-Prot
      O35326
      UniProtKB/TrEMBL
      Q9D8S5
      Conserved Domains (2) summary
      cd12337
      Location:571
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:108178
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    5. NM_009159.3NP_033185.2  serine/arginine-rich splicing factor 5 isoform 1

      See identical proteins and their annotated locations for NP_033185.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AA388848, AC125092, AK146624
      Consensus CDS
      CCDS36484.1
      UniProtKB/Swiss-Prot
      O35326
      Related
      ENSMUSP00000105981.3, OTTMUSP00000023357, ENSMUST00000110352.9, OTTMUST00000050123
      Conserved Domains (2) summary
      cd12337
      Location:571
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:108178
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      80945504..80950507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515631.1XP_006515694.1  serine/arginine-rich splicing factor 5 isoform X1

      Conserved Domains (2) summary
      cd12337
      Location:571
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:108178
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    2. XM_006515629.3XP_006515692.1  serine/arginine-rich splicing factor 5 isoform X1

      Related
      ENSMUSP00000105980.1, OTTMUSP00000023358, ENSMUST00000110351.7, OTTMUST00000050125
      Conserved Domains (2) summary
      cd12337
      Location:571
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:108178
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    3. XM_006515630.3XP_006515693.1  serine/arginine-rich splicing factor 5 isoform X1

      See identical proteins and their annotated locations for XP_006515693.1

      UniProtKB/TrEMBL
      Q9D8S5
      Conserved Domains (2) summary
      cd12337
      Location:571
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:108178
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
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