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    Selenow selenoprotein W [ Mus musculus (house mouse) ]

    Gene ID: 20364, updated on 23-Jun-2021

    Summary

    Official Symbol
    Selenowprovided by MGI
    Official Full Name
    selenoprotein Wprovided by MGI
    Primary source
    MGI:MGI:1100878
    See related
    Ensembl:ENSMUSG00000041571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sep; selW; Sepw1
    Summary
    This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, and has been shown to function as a glutathione-dependent antioxidant in vivo. Studies in mouse suggest that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 402.4), cortex adult (RPKM 391.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Selenow in Genome Data Viewer
    Location:
    7; 7 A2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15651133..15656296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (15917208..15922371, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (16502557..16507720, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cone-rod homeobox, opposite strand Neighboring gene argininosuccinate synthetase pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene NOP53 ribosome biogenesis factor Neighboring gene predicted gene, 24576 Neighboring gene EH-domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1)  1 citation

    Pathways from PubChem

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in response to selenium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    selenoprotein W
    Names
    selenoprotein W, muscle 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009156.2NP_033182.1  selenoprotein W

      See identical proteins and their annotated locations for NP_033182.1

      Status: REVIEWED

      Source sequence(s)
      AF015284, BU604713
      Consensus CDS
      CCDS39778.1
      UniProtKB/Swiss-Prot
      P63300
      Related
      ENSMUSP00000038943.9, ENSMUST00000044355.11
      Conserved Domains (1) summary
      TIGR02174
      Location:577
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      15651133..15656296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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