U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ADAM32 ADAM metallopeptidase domain 32 [ Homo sapiens (human) ]

    Gene ID: 203102, updated on 3-Apr-2024

    Summary

    Official Symbol
    ADAM32provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 32provided by HGNC
    Primary source
    HGNC:HGNC:15479
    See related
    Ensembl:ENSG00000197140 MIM:618602; AllianceGenome:HGNC:15479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Restricted expression toward testis (RPKM 20.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAM32 in Genome Data Viewer
    Location:
    8p11.22
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (39107529..39284917)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (39384664..39562013)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38965048..39142436)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853156-38853678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853679-38854200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27277 Neighboring gene TM2 domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 279 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene small nucleolar RNA, C/D box 38D Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:39038237-39039436 Neighboring gene ribosomal protein L3 pseudogene 10 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:39084432-39085631 Neighboring gene lysine acetyltransferase 2B pseudogene Neighboring gene ADAM metallopeptidase domain 5 (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26299, FLJ29004

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 32
    Names
    a disintegrin and metalloprotease domain 32
    a disintegrin and metalloproteinase domain 32
    metalloproteinase 12-like protein
    testicular tissue protein Li 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313994.1NP_001300923.1  disintegrin and metalloproteinase domain-containing protein 32 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple alternate exons in the coding region and uses an alternate translation start site, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC105091, AK300148, BC026169, BI559590
      Consensus CDS
      CCDS83286.1
      UniProtKB/TrEMBL
      B4DTC2, E7EPX8
      Related
      ENSP00000405978.2, ENST00000437682.6
      Conserved Domains (5) summary
      cd04269
      Location:194312
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:313376
      Disintegrin; Disintegrin
      pfam01562
      Location:45150
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:380494
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:615687
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    2. NM_145004.7NP_659441.4  disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC105091, AC105185
      Consensus CDS
      CCDS47846.1
      UniProtKB/Swiss-Prot
      Q8TC27, Q8TC42
      UniProtKB/TrEMBL
      A0A140VJD9
      Related
      ENSP00000369238.4, ENST00000379907.9
      Conserved Domains (5) summary
      pfam00200
      Location:400474
      Disintegrin; Disintegrin
      pfam01421
      Location:187383
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:27144
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:479593
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:714786
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      39107529..39284917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544433.3XP_011542735.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A140VJD9
      Conserved Domains (6) summary
      cd04269
      Location:187381
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:400475
      Disintegrin; Disintegrin
      pfam01421
      Location:187383
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40143
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:479593
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:714773
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    2. XM_006716298.4XP_006716361.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

      UniProtKB/TrEMBL
      A0A140VJD9
      Conserved Domains (5) summary
      cd04269
      Location:187381
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:400475
      Disintegrin; Disintegrin
      pfam01421
      Location:187383
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40143
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:479593
      ADAM_CR; ADAM cysteine-rich
    3. XM_017013184.3XP_016868673.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

      UniProtKB/TrEMBL
      A0A140VJD9
    4. XM_006716299.3XP_006716362.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

      UniProtKB/TrEMBL
      E7ER82
      Related
      ENSP00000429422.1, ENST00000519315.5
      Conserved Domains (5) summary
      cd04269
      Location:187305
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:306369
      Disintegrin; Disintegrin
      pfam01562
      Location:40143
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:373487
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:608680
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    5. XM_011544434.3XP_011542736.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

      UniProtKB/TrEMBL
      E7ER82
      Conserved Domains (6) summary
      cd04269
      Location:187308
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:327402
      Disintegrin; Disintegrin
      pfam01421
      Location:187310
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40143
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:406520
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:641713
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    6. XM_017013183.3XP_016868672.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

      UniProtKB/TrEMBL
      A0A140VJD9
    7. XM_047421494.1XP_047277450.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    8. XM_017013186.3XP_016868675.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

    9. XM_017013185.3XP_016868674.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

      UniProtKB/TrEMBL
      A0A140VJD9
    10. XM_017013188.2XP_016868677.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

    11. XM_017013187.2XP_016868676.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187577.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      13212..190632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328846.1XP_054184821.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

    2. XM_054328845.1XP_054184820.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    3. XM_054328848.1XP_054184823.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

    4. XM_054328851.1XP_054184826.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

    5. XM_054328852.1XP_054184827.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X12

    6. XM_054328850.1XP_054184825.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

    7. XM_054328847.1XP_054184822.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

    8. XM_054328854.1XP_054184829.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    9. XM_054328853.1XP_054184828.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

    10. XM_054328849.1XP_054184824.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

    11. XM_054328857.1XP_054184832.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

    12. XM_054328855.1XP_054184830.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

    13. XM_054328856.1XP_054184831.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      39384664..39562013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360000.1XP_054215975.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

    2. XM_054359999.1XP_054215974.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    3. XM_054360002.1XP_054215977.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

    4. XM_054360005.1XP_054215980.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

    5. XM_054360006.1XP_054215981.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X14

    6. XM_054360004.1XP_054215979.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

    7. XM_054360001.1XP_054215976.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

    8. XM_054360008.1XP_054215983.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    9. XM_054360007.1XP_054215982.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

    10. XM_054360003.1XP_054215978.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

    11. XM_054360010.1XP_054215985.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

    12. XM_054360009.1XP_054215984.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10