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    TSNARE1 t-SNARE domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 203062, updated on 21-May-2024

    Summary

    Official Symbol
    TSNARE1provided by HGNC
    Official Full Name
    t-SNARE domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:26437
    See related
    Ensembl:ENSG00000171045 AllianceGenome:HGNC:26437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in skin (RPKM 3.2), ovary (RPKM 2.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSNARE1 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142212080..142407029, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143351850..143548446, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143293441..143484543, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375792 Neighboring gene Sharpr-MPRA regulatory region 1162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143283162-143283882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143284603-143285322 Neighboring gene long intergenic non-protein coding RNA 51 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143300684-143301572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143341408-143341908 Neighboring gene RNA, 7SL, cytoplasmic 260, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143375399-143375900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143419370-143420072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143425450-143425965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143424933-143425449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143436639-143437406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143441158-143441658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143457662-143458237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143458238-143458812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143477973-143478474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143484673-143485448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143491197-143491875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143497207-143498198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143498199-143499188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143508526-143509300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143515169-143515669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143534525-143535456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143535457-143536388 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143545037-143545542 Neighboring gene uncharacterized LOC124902075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143550893-143551634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143551635-143552376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143553119-143553858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19599 Neighboring gene adhesion G protein-coupled receptor B1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143587077-143587778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143590247-143591018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143591019-143591788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143594079-143594580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143594581-143595080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143608973-143609474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143626930-143627856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143636183-143636684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143636685-143637184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143647608-143648108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143653071-143653734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143656141-143656686 Neighboring gene maestro heat like repeat family member 4, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31164, MGC142116

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    t-SNARE domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291931.2NP_001278860.1  t-SNARE domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive in-frame exons in the 5' coding region, uses an alternate in-frame splice site in the central coding region, and also lacks two 3' exons but contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC103758, AI203371, BC065226, BF529741, BX115133, HY009343, HY264564
      Consensus CDS
      CCDS78369.1
      UniProtKB/TrEMBL
      E5RHT3, Q6P186
      Related
      ENSP00000429679.1, ENST00000519651.5
      Conserved Domains (2) summary
      pfam14523
      Location:46146
      Syntaxin_2; Syntaxin-like protein
      cl22856
      Location:197260
      SNARE; SNARE motif
    2. NM_001363740.2NP_001350669.1  t-SNARE domain-containing protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC103758, AC134682, AK055726, BC126343
      Consensus CDS
      CCDS87630.1
      UniProtKB/TrEMBL
      A0AVG3, B7ZLB1, E5RG83
      Related
      ENSP00000303437.4, ENST00000307180.4
      Conserved Domains (3) summary
      cd15877
      Location:417480
      SNARE_TSNARE1; SNARE motif of TSNARE1
      pfam13873
      Location:124201
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265366
      Syntaxin_2; Syntaxin-like protein
    3. NM_001366901.1NP_001353830.1  t-SNARE domain-containing protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC103758, AC134682, BC143684
      UniProtKB/TrEMBL
      B7ZLB1
      Conserved Domains (3) summary
      cd15877
      Location:415478
      SNARE_TSNARE1; SNARE motif of TSNARE1
      pfam13873
      Location:124201
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265365
      Syntaxin_2; Syntaxin-like protein
    4. NM_001366902.1NP_001353831.1  t-SNARE domain-containing protein 1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC103758, AC129918, AC134682
      UniProtKB/TrEMBL
      B7ZLB1
      Conserved Domains (2) summary
      pfam13873
      Location:124201
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265366
      Syntaxin_2; Syntaxin-like protein
    5. NM_001366903.1NP_001353832.1  t-SNARE domain-containing protein 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC103758, AC129918, AC134682
      UniProtKB/TrEMBL
      B7ZLB1
      Conserved Domains (2) summary
      pfam13873
      Location:124201
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265365
      Syntaxin_2; Syntaxin-like protein
    6. NM_001366904.1NP_001353833.1  t-SNARE domain-containing protein 1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC103758, AC129918, AC134682, KC877361
      UniProtKB/TrEMBL
      B7ZLB1
      Conserved Domains (3) summary
      cd15877
      Location:416479
      SNARE_TSNARE1; SNARE motif of TSNARE1
      pfam13873
      Location:124201
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265366
      Syntaxin_2; Syntaxin-like protein
    7. NM_145003.5NP_659440.2  t-SNARE domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_659440.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      AC103758, AK055726, BC113556, HY009343
      Consensus CDS
      CCDS6384.1
      UniProtKB/Swiss-Prot
      B7ZLB0, Q14D03, Q96NA8
      UniProtKB/TrEMBL
      B7ZLB1
      Related
      ENSP00000428763.2, ENST00000524325.6
      Conserved Domains (3) summary
      cd15877
      Location:416479
      SNARE_TSNARE1; SNARE motif of TSNARE1
      pfam13873
      Location:124201
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265366
      Syntaxin_2; Syntaxin-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      142212080..142407029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421491.1XP_047277447.1  t-SNARE domain-containing protein 1 isoform X37

    2. XM_047421483.1XP_047277439.1  t-SNARE domain-containing protein 1 isoform X28

    3. XM_047421488.1XP_047277444.1  t-SNARE domain-containing protein 1 isoform X35

    4. XM_047421487.1XP_047277443.1  t-SNARE domain-containing protein 1 isoform X34

    5. XM_047421484.1XP_047277440.1  t-SNARE domain-containing protein 1 isoform X29

    6. XM_047421486.1XP_047277442.1  t-SNARE domain-containing protein 1 isoform X33

    7. XM_047421485.1XP_047277441.1  t-SNARE domain-containing protein 1 isoform X32

    8. XM_011516912.3XP_011515214.1  t-SNARE domain-containing protein 1 isoform X5

      Conserved Domains (3) summary
      pfam13873
      Location:124198
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265366
      Syntaxin_2; Syntaxin-like protein
      cl22856
      Location:416456
      SNARE; SNARE motif
    9. XM_047421473.1XP_047277429.1  t-SNARE domain-containing protein 1 isoform X18

    10. XM_017013179.2XP_016868668.1  t-SNARE domain-containing protein 1 isoform X31

      UniProtKB/TrEMBL
      B7ZLB1
    11. XM_047421480.1XP_047277436.1  t-SNARE domain-containing protein 1 isoform X25

      Related
      ENSP00000499343.2, ENST00000662555.2
    12. XM_047421475.1XP_047277431.1  t-SNARE domain-containing protein 1 isoform X20

    13. XM_047421476.1XP_047277432.1  t-SNARE domain-containing protein 1 isoform X21

    14. XM_047421481.1XP_047277437.1  t-SNARE domain-containing protein 1 isoform X26

    15. XM_011516921.2XP_011515223.1  t-SNARE domain-containing protein 1 isoform X30

      UniProtKB/TrEMBL
      B7ZLB1
      Conserved Domains (3) summary
      cd15877
      Location:416479
      SNARE_TSNARE1; SNARE motif of TSNARE1
      pfam13873
      Location:124198
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265365
      Syntaxin_2; Syntaxin-like protein
    16. XM_047421482.1XP_047277438.1  t-SNARE domain-containing protein 1 isoform X27

    17. XM_047421459.1XP_047277415.1  t-SNARE domain-containing protein 1 isoform X3

    18. XM_047421472.1XP_047277428.1  t-SNARE domain-containing protein 1 isoform X17

    19. XM_047421466.1XP_047277422.1  t-SNARE domain-containing protein 1 isoform X11

    20. XM_047421474.1XP_047277430.1  t-SNARE domain-containing protein 1 isoform X19

    21. XM_047421461.1XP_047277417.1  t-SNARE domain-containing protein 1 isoform X6

    22. XM_047421471.1XP_047277427.1  t-SNARE domain-containing protein 1 isoform X16

    23. XM_047421462.1XP_047277418.1  t-SNARE domain-containing protein 1 isoform X7

    24. XM_047421479.1XP_047277435.1  t-SNARE domain-containing protein 1 isoform X24

    25. XM_047421478.1XP_047277434.1  t-SNARE domain-containing protein 1 isoform X23

    26. XM_047421477.1XP_047277433.1  t-SNARE domain-containing protein 1 isoform X22

    27. XM_047421470.1XP_047277426.1  t-SNARE domain-containing protein 1 isoform X15

    28. XM_047421469.1XP_047277425.1  t-SNARE domain-containing protein 1 isoform X14

    29. XM_047421468.1XP_047277424.1  t-SNARE domain-containing protein 1 isoform X13

    30. XM_047421460.1XP_047277416.1  t-SNARE domain-containing protein 1 isoform X4

    31. XM_047421465.1XP_047277421.1  t-SNARE domain-containing protein 1 isoform X10

    32. XM_047421464.1XP_047277420.1  t-SNARE domain-containing protein 1 isoform X9

    33. XM_047421457.1XP_047277413.1  t-SNARE domain-containing protein 1 isoform X1

    34. XM_047421463.1XP_047277419.1  t-SNARE domain-containing protein 1 isoform X8

    35. XM_047421458.1XP_047277414.1  t-SNARE domain-containing protein 1 isoform X2

    36. XM_047421467.1XP_047277423.1  t-SNARE domain-containing protein 1 isoform X12

    37. XM_047421490.1XP_047277446.1  t-SNARE domain-containing protein 1 isoform X36

    38. XM_047421489.1XP_047277445.1  t-SNARE domain-containing protein 1 isoform X36

    39. XM_011516924.2XP_011515226.1  t-SNARE domain-containing protein 1 isoform X38

      Conserved Domains (2) summary
      pfam13873
      Location:124198
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain
      pfam14523
      Location:265298
      Syntaxin_2; Syntaxin-like protein

    RNA

    1. XR_007060718.1 RNA Sequence

    2. XR_007060717.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      143351850..143548446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359991.1XP_054215966.1  t-SNARE domain-containing protein 1 isoform X37

    2. XM_054359981.1XP_054215956.1  t-SNARE domain-containing protein 1 isoform X28

    3. XM_054359988.1XP_054215963.1  t-SNARE domain-containing protein 1 isoform X35

    4. XM_054359987.1XP_054215962.1  t-SNARE domain-containing protein 1 isoform X34

    5. XM_054359986.1XP_054215961.1  t-SNARE domain-containing protein 1 isoform X29

    6. XM_054359985.1XP_054215960.1  t-SNARE domain-containing protein 1 isoform X33

    7. XM_054359984.1XP_054215959.1  t-SNARE domain-containing protein 1 isoform X32

    8. XM_054359958.1XP_054215933.1  t-SNARE domain-containing protein 1 isoform X5

    9. XM_054359971.1XP_054215946.1  t-SNARE domain-containing protein 1 isoform X18

    10. XM_054359983.1XP_054215958.1  t-SNARE domain-containing protein 1 isoform X31

    11. XM_054359978.1XP_054215953.1  t-SNARE domain-containing protein 1 isoform X25

    12. XM_054359973.1XP_054215948.1  t-SNARE domain-containing protein 1 isoform X20

    13. XM_054359974.1XP_054215949.1  t-SNARE domain-containing protein 1 isoform X21

    14. XM_054359979.1XP_054215954.1  t-SNARE domain-containing protein 1 isoform X26

    15. XM_054359982.1XP_054215957.1  t-SNARE domain-containing protein 1 isoform X30

    16. XM_054359980.1XP_054215955.1  t-SNARE domain-containing protein 1 isoform X27

    17. XM_054359956.1XP_054215931.1  t-SNARE domain-containing protein 1 isoform X3

    18. XM_054359970.1XP_054215945.1  t-SNARE domain-containing protein 1 isoform X17

    19. XM_054359964.1XP_054215939.1  t-SNARE domain-containing protein 1 isoform X11

    20. XM_054359972.1XP_054215947.1  t-SNARE domain-containing protein 1 isoform X19

    21. XM_054359959.1XP_054215934.1  t-SNARE domain-containing protein 1 isoform X6

    22. XM_054359967.1XP_054215942.1  t-SNARE domain-containing protein 1 isoform X14

    23. XM_054359966.1XP_054215941.1  t-SNARE domain-containing protein 1 isoform X13

    24. XM_054359962.1XP_054215937.1  t-SNARE domain-containing protein 1 isoform X9

    25. XM_054359954.1XP_054215929.1  t-SNARE domain-containing protein 1 isoform X1

    26. XM_054359961.1XP_054215936.1  t-SNARE domain-containing protein 1 isoform X8

    27. XM_054359968.1XP_054215943.1  t-SNARE domain-containing protein 1 isoform X15

    28. XM_054359957.1XP_054215932.1  t-SNARE domain-containing protein 1 isoform X4

    29. XM_054359969.1XP_054215944.1  t-SNARE domain-containing protein 1 isoform X16

    30. XM_054359960.1XP_054215935.1  t-SNARE domain-containing protein 1 isoform X7

    31. XM_054359977.1XP_054215952.1  t-SNARE domain-containing protein 1 isoform X23

    32. XM_054359976.1XP_054215951.1  t-SNARE domain-containing protein 1 isoform X24

    33. XM_054359975.1XP_054215950.1  t-SNARE domain-containing protein 1 isoform X22

    34. XM_054359963.1XP_054215938.1  t-SNARE domain-containing protein 1 isoform X10

    35. XM_054359955.1XP_054215930.1  t-SNARE domain-containing protein 1 isoform X2

    36. XM_054359965.1XP_054215940.1  t-SNARE domain-containing protein 1 isoform X12

    37. XM_054359990.1XP_054215965.1  t-SNARE domain-containing protein 1 isoform X36

    38. XM_054359989.1XP_054215964.1  t-SNARE domain-containing protein 1 isoform X36

    39. XM_054359992.1XP_054215967.1  t-SNARE domain-containing protein 1 isoform X38

    RNA

    1. XR_008487818.1 RNA Sequence