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    Sars seryl-aminoacyl-tRNA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 20226, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sarsprovided by MGI
    Official Full Name
    seryl-aminoacyl-tRNA synthetaseprovided by MGI
    Primary source
    MGI:MGI:102809
    See related
    Ensembl:ENSMUSG00000068739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; Strs; Sars1; serRS
    Expression
    Ubiquitous expression in CNS E14 (RPKM 31.6), CNS E11.5 (RPKM 30.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sars in Genome Data Viewer
    Location:
    3 F3; 3 47.08 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108332180..108352575, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108424864..108445259, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (108229530..108248087, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene proline/serine-rich coiled-coil 1 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene predicted gene, 52630 Neighboring gene predicted gene, 22942 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator 1 Neighboring gene predicted gene, 23336 Neighboring gene RIKEN cDNA 1700013F07 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine--tRNA ligase, cytoplasmic
    Names
    seryl-aminoacyl-tRNA synthetase 1
    seryl-tRNA synthetase, cytoplasmic
    seryl-tRNA(Ser/Sec) synthetase
    NP_001191908.1
    NP_035449.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204979.1NP_001191908.1  serine--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001191908.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK028358, AK075827, BP765728, BY034232
      Consensus CDS
      CCDS57254.1
      UniProtKB/Swiss-Prot
      P26638
      Related
      ENSMUSP00000088041.6, ENSMUST00000090553.12
      Conserved Domains (3) summary
      PLN02678
      Location:3486
      PLN02678; seryl-tRNA synthetase
      cd00770
      Location:152460
      SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
      pfam02403
      Location:3109
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
    2. NM_011319.3NP_035449.1  serine--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_035449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK028358, AK082793, BP765728, BY034232
      Consensus CDS
      CCDS17760.1
      UniProtKB/TrEMBL
      Q8C483
      Related
      ENSMUSP00000099685.5, ENSMUST00000102625.11
      Conserved Domains (3) summary
      PLN02678
      Location:3510
      PLN02678; seryl-tRNA synthetase
      cd00770
      Location:152484
      SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
      pfam02403
      Location:3109
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      108332180..108352575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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