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    Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 20218, updated on 2-Aug-2021

    Summary

    Official Symbol
    Khdrbs1provided by MGI
    Official Full Name
    KH domain containing, RNA binding, signal transduction associated 1provided by MGI
    Primary source
    MGI:MGI:893579
    See related
    Ensembl:ENSMUSG00000028790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p6; Sam; p62; p68; Sam68
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.4), thymus adult (RPKM 9.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Khdrbs1 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129596143..129637402, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129702380..129743878, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (129392103..129419526, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene karyopherin (importin) alpha 6 Neighboring gene transmembrane protein 39b Neighboring gene microRNA 7016 Neighboring gene predicted gene 12967 Neighboring gene protein tyrosine phosphatase 4a2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Grb2-Sos complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    KH domain-containing, RNA-binding, signal transduction-associated protein 1
    Names
    GAP-associated tyrosine phosphoprotein p62
    p21 Ras GTPase-activating protein-associated p62
    src associated in mitosis, 68 kDa
    src-associated in mitosis 68 kDa protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011317.4NP_035447.3  KH domain-containing, RNA-binding, signal transduction-associated protein 1

      See identical proteins and their annotated locations for NP_035447.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK044927, AK152084, BE986307, CJ055187
      Consensus CDS
      CCDS18703.1
      UniProtKB/Swiss-Prot
      Q60749
      Related
      ENSMUSP00000066516.6, ENSMUST00000066257.6
      Conserved Domains (3) summary
      cd02395
      Location:157276
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16274
      Location:103153
      Qua1; Qua1 domain
      pfam16568
      Location:366415
      Sam68-YY; Tyrosine-rich domain of Sam68

    RNA

    1. NR_045036.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and includes three novel exons in the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK050520, BB054974, CJ055187, EL606063

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129596143..129637402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_376300.4 RNA Sequence

    2. XR_001784112.3 RNA Sequence

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