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    Ryk receptor-like tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 20187, updated on 16-Aug-2021

    Summary

    Official Symbol
    Rykprovided by MGI
    Official Full Name
    receptor-like tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:101766
    See related
    Ensembl:ENSMUSG00000032547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V; Vik; ERK-; ERK-3; AW536699
    Expression
    Ubiquitous expression in bladder adult (RPKM 22.9), lung adult (RPKM 22.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ryk in Genome Data Viewer
    Location:
    9 F1; 9 54.72 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (102712119..102785506)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (102834920..102908307)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (102737250..102810637)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46151 Neighboring gene cytoskeleton associated protein 5 pseudogene Neighboring gene predicted gene, 31434 Neighboring gene solute carrier organic anion transporter family, member 2a1 Neighboring gene predicted gene, 22595

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Wnt-activated receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt-activated receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt-protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chemorepulsion of axon TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chemorepulsion of dopaminergic neuron axon IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within commissural neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase RYK
    Names
    NYK-R
    growth factor receptor
    kinase VIK
    met-related kinase
    NP_001036072.1
    NP_001271187.1
    NP_038677.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042607.1NP_001036072.1  tyrosine-protein kinase RYK isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK144355, BB704205, L02210, L21707
      Consensus CDS
      CCDS57696.1
      UniProtKB/Swiss-Prot
      Q01887
      UniProtKB/TrEMBL
      H9H9R6
      Related
      ENSMUSP00000035142.7, ENSMUST00000035142.8
      Conserved Domains (3) summary
      smart00469
      Location:47180
      WIF; Wnt-inhibitory factor-1 like domain
      cd05043
      Location:307587
      PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
      pfam07714
      Location:314580
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001284258.1NP_001271187.1  tyrosine-protein kinase RYK isoform 3

      See identical proteins and their annotated locations for NP_001271187.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lack an alternate in-frame 5' coding exon and initiates translation at a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC164161, AK144355
      UniProtKB/TrEMBL
      Q8K272
      Conserved Domains (3) summary
      cd05043
      Location:191471
      PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
      pfam07714
      Location:198464
      Pkinase_Tyr; Protein tyrosine kinase
      cl02623
      Location:164
      WIF; WIF domain
    3. NM_013649.3NP_038677.3  tyrosine-protein kinase RYK isoform 1 precursor

      See identical proteins and their annotated locations for NP_038677.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK076449, AK144355, BB704205, L02210, L21707
      Consensus CDS
      CCDS40747.1
      UniProtKB/Swiss-Prot
      Q01887
      Related
      ENSMUSP00000135858.2, ENSMUST00000175883.8
      Conserved Domains (3) summary
      smart00469
      Location:47180
      WIF; Wnt-inhibitory factor-1 like domain
      cd05043
      Location:310590
      PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
      pfam07714
      Location:317583
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      102712119..102785506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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