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    Uimc1 ubiquitin interaction motif containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 20184, updated on 23-Jun-2021

    Summary

    Official Symbol
    Uimc1provided by MGI
    Official Full Name
    ubiquitin interaction motif containing 1provided by MGI
    Primary source
    MGI:MGI:103185
    See related
    Ensembl:ENSMUSG00000025878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rxri; RIP110; Rxrip110; 9430016E08Rik; D330018D10Rik; D630032M02Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 8.1), CNS E11.5 (RPKM 7.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Uimc1 in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55175693..55248176, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55027880..55100363, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55129241..55201656, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31313 Neighboring gene unc-5 netrin receptor A Neighboring gene hexokinase 3 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene zinc finger protein 346 Neighboring gene predicted gene, 46415 Neighboring gene fibroblast growth factor receptor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinoid X receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H2A K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H2A K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of BRCA1-A complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    BRCA1-A complex subunit RAP80
    Names
    receptor-associated protein 80
    retinoid X receptor interacting protein 110
    ubiquitin interaction motif-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293660.1NP_001280589.1  BRCA1-A complex subunit RAP80 isoform 2

      See identical proteins and their annotated locations for NP_001280589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK052704, AK160926
      Consensus CDS
      CCDS79189.1
      UniProtKB/Swiss-Prot
      Q5U5Q9
      UniProtKB/TrEMBL
      A0A0R4J183
      Related
      ENSMUSP00000097095.4, ENSMUST00000099496.4
      Conserved Domains (1) summary
      pfam18282
      Location:72122
      RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
    2. NM_001359757.1NP_001346686.1  BRCA1-A complex subunit RAP80 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AC154610
      Consensus CDS
      CCDS36671.1
    3. NM_001359758.1NP_001346687.1  BRCA1-A complex subunit RAP80 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains multiple differences in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC154610
    4. NM_011307.3NP_035437.1  BRCA1-A complex subunit RAP80 isoform 1

      See identical proteins and their annotated locations for NP_035437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK052704, AK160926
      Consensus CDS
      CCDS36671.1
      UniProtKB/Swiss-Prot
      Q5U5Q9
      UniProtKB/TrEMBL
      A0A0R4J073
      Related
      ENSMUSP00000026997.6, ENSMUST00000026997.12

    RNA

    1. NR_121592.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK052704, AK160926
      Related
      ENSMUST00000148702.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55175693..55248176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244499.3XP_011242801.1  BRCA1-A complex subunit RAP80 isoform X2

      Conserved Domains (1) summary
      pfam18282
      Location:72128
      RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
    2. XM_030247207.2XP_030103067.1  BRCA1-A complex subunit RAP80 isoform X6

      Conserved Domains (1) summary
      pfam18282
      Location:72122
      RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
    3. XM_006517167.4XP_006517230.1  BRCA1-A complex subunit RAP80 isoform X1

      Conserved Domains (1) summary
      pfam18282
      Location:72128
      RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
    4. XM_036157929.1XP_036013822.1  BRCA1-A complex subunit RAP80 isoform X4

      Conserved Domains (1) summary
      cd20912
      Location:122
      AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains
    5. XM_036157930.1XP_036013823.1  BRCA1-A complex subunit RAP80 isoform X5

    6. XM_036157928.1XP_036013821.1  BRCA1-A complex subunit RAP80 isoform X3

      Conserved Domains (1) summary
      pfam18282
      Location:72122
      RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

    RNA

    1. XR_004937982.1 RNA Sequence

    2. XR_004937981.1 RNA Sequence

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