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    Uimc1 ubiquitin interaction motif containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 20184, updated on 2-Oct-2018

    Summary

    Official Symbol
    Uimc1provided by MGI
    Official Full Name
    ubiquitin interaction motif containing 1provided by MGI
    Primary source
    MGI:MGI:103185
    See related
    Ensembl:ENSMUSG00000025878 Vega:OTTMUSG00000032667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RIP110; Rxrip110; 9430016E08Rik; D330018D10Rik; D630032M02Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 8.1), CNS E11.5 (RPKM 7.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See Uimc1 in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (55027880..55100309, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55129241..55201656, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31313 Neighboring gene unc-5 netrin receptor A Neighboring gene hexokinase 3 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene zinc finger protein 346 Neighboring gene predicted gene, 46415 Neighboring gene fibroblast growth factor receptor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    retinoid X receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    histone H2A K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H2A K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction involved in G2 DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    BRCA1-A complex ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    BRCA1-A complex subunit RAP80
    Names
    receptor-associated protein 80
    retinoid X receptor interacting protein 110
    ubiquitin interaction motif-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293660.1NP_001280589.1  BRCA1-A complex subunit RAP80 isoform 2

      See identical proteins and their annotated locations for NP_001280589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK052704, AK160926
      Consensus CDS
      CCDS79189.1
      UniProtKB/Swiss-Prot
      Q5U5Q9
      UniProtKB/TrEMBL
      A0A0R4J183
      Related
      ENSMUSP00000097095.3, OTTMUSP00000043432, ENSMUST00000099496.3, OTTMUST00000081250
    2. NM_001359757.1NP_001346686.1  BRCA1-A complex subunit RAP80 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AC154610
    3. NM_001359758.1NP_001346687.1  BRCA1-A complex subunit RAP80 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains multiple differences in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC154610
    4. NM_011307.3NP_035437.1  BRCA1-A complex subunit RAP80 isoform 1

      See identical proteins and their annotated locations for NP_035437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK052704, AK160926
      Consensus CDS
      CCDS36671.1
      UniProtKB/Swiss-Prot
      Q5U5Q9
      UniProtKB/TrEMBL
      A0A0R4J073
      Related
      ENSMUSP00000026997.5, ENSMUST00000026997.11

    RNA

    1. NR_121592.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK052704, AK160926
      Related
      ENSMUST00000148702.7, OTTMUST00000081254

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      55027880..55100309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517167.2XP_006517230.1  BRCA1-A complex subunit RAP80 isoform X2

    2. XM_006517169.3XP_006517232.1  BRCA1-A complex subunit RAP80 isoform X4

    3. XM_006517166.2XP_006517229.1  BRCA1-A complex subunit RAP80 isoform X1

      UniProtKB/Swiss-Prot
      Q5U5Q9
      UniProtKB/TrEMBL
      A0A0R4J073
    4. XM_011244499.1XP_011242801.1  BRCA1-A complex subunit RAP80 isoform X3

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