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    ZSCAN4 zinc finger and SCAN domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 201516, updated on 2-Oct-2018

    Summary

    Official Symbol
    ZSCAN4provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:23709
    See related
    Ensembl:ENSG00000180532 MIM:613419; Vega:OTTHUMG00000183474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF494
    Summary
    The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See ZSCAN4 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (57651497..57679152)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58180303..58190520)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 134 Neighboring gene zinc finger protein 211 Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene zinc finger protein 551 Neighboring gene zinc finger protein 154

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
      Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ35105, MGC126787, MGC126789

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of mitotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger and SCAN domain-containing protein 4
    Names
    zinc finger protein 494

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152677.2NP_689890.1  zinc finger and SCAN domain-containing protein 4

      See identical proteins and their annotated locations for NP_689890.1

      Status: VALIDATED

      Source sequence(s)
      AC004017, AK092424, BX118882
      Consensus CDS
      CCDS12958.1
      UniProtKB/Swiss-Prot
      Q8NAM6
      Related
      ENSP00000321963.4, OTTHUMP00000271791, ENST00000318203.9, OTTHUMT00000466812
      Conserved Domains (5) summary
      smart00431
      Location:40148
      SCAN; leucine rich region
      cd07936
      Location:40124
      SCAN; SCAN oligomerization domain
      sd00017
      Location:342362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:312334
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:382407
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      57651497..57679152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526607.2XP_011524909.1  zinc finger and SCAN domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011524909.1

      UniProtKB/Swiss-Prot
      Q8NAM6
      Conserved Domains (5) summary
      smart00431
      Location:40148
      SCAN; leucine rich region
      cd07936
      Location:40124
      SCAN; SCAN oligomerization domain
      sd00017
      Location:342362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:312334
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:382407
      zf-H2C2_2; Zinc-finger double domain
    2. XM_017026458.1XP_016881947.1  zinc finger and SCAN domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8NAM6
      Conserved Domains (5) summary
      smart00431
      Location:40148
      SCAN; leucine rich region
      cd07936
      Location:40124
      SCAN; SCAN oligomerization domain
      sd00017
      Location:342362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:312334
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:382407
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_001753629.1 RNA Sequence

    2. XR_001753630.1 RNA Sequence

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