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    ZBTB7C zinc finger and BTB domain containing 7C [ Homo sapiens (human) ]

    Gene ID: 201501, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZBTB7Cprovided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 7Cprovided by HGNC
    Primary source
    HGNC:HGNC:31700
    See related
    Ensembl:ENSG00000184828 MIM:616591; AllianceGenome:HGNC:31700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APM1; APM-1; ZBTB36; ZNF857C
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell population proliferation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in esophagus (RPKM 8.6), skin (RPKM 4.3) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZBTB7C in Genome Data Viewer
    Location:
    18q21.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (48026672..48412585, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (48217704..48603693, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (45553043..45938956, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904297 Neighboring gene uncharacterized LOC105372101 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:45494112-45494840 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:45499951-45500451 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:45529319-45530518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:45534013-45534926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45580577-45581077 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:45605776-45606698 Neighboring gene Sharpr-MPRA regulatory region 9251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:45654098-45654696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45665409-45665908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45698538-45699038 Neighboring gene ZBTB7C antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45712074-45712592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45712593-45713110 Neighboring gene RNA, U6 small nuclear 708, pseudogene Neighboring gene ZBTB7C antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45819913-45820696 Neighboring gene Sharpr-MPRA regulatory region 937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45822263-45823044 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:45844425-45844926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45861441-45861941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45860940-45861440 Neighboring gene uncharacterized LOC124904352 Neighboring gene uncharacterized LOC124904353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45934035-45934654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:45934655-45935272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9432 Neighboring gene Sharpr-MPRA regulatory region 5458 Neighboring gene RNA, 5S ribosomal pseudogene 456 Neighboring gene RNA polymerase III subunit G pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
    EBI GWAS Catalog
    Genome-wide association study in Han Chinese identifies three novel loci for human height.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37907

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 7C
    Names
    B230208J24Rik
    affected by papillomavirus DNA integration in ME180 cells protein 1
    zinc finger and BTB domain containing 36
    zinc finger and BTB domain-containing protein 36
    zinc finger protein 857C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039360.3NP_001034449.1  zinc finger and BTB domain-containing protein 7C

      See identical proteins and their annotated locations for NP_001034449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC105042, AM988836, CD366839, EF120357
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Related
      ENSP00000439781.1, ENST00000535628.6
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    2. NM_001318841.2NP_001305770.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC105042, AM988839, BM983365
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Related
      ENSP00000467877.1, ENST00000590800.6
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    3. NM_001371284.1NP_001358213.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Source sequence(s)
      AC105042, AM988839, AM991966
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    4. NM_001371285.1NP_001358214.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Source sequence(s)
      AC105042, AM988839, AM991284
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Related
      ENSP00000468782.1, ENST00000588982.5
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    5. NM_001371286.1NP_001358215.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Source sequence(s)
      AC024288, AC105042, AM988839, AM991285
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    6. NM_001371287.1NP_001358216.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Source sequence(s)
      AC024288, AC105042, AM988839, AM989328, AM991966
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    7. NM_001371288.1NP_001358217.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Source sequence(s)
      AC091150, AC105042, AM988839, AM991277
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    8. NM_001371290.1NP_001358219.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Source sequence(s)
      AC024288, AC105042, AM988839, AM989330, AM991970
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    9. NM_001371291.1NP_001358220.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Source sequence(s)
      AC024288, AC105042, AM988839, AM989330, AM991969
      Consensus CDS
      CCDS32830.1
      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      48026672..48412585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437347.1XP_047293303.1  zinc finger and BTB domain-containing protein 7C isoform X2

    2. XM_047437346.1XP_047293302.1  zinc finger and BTB domain-containing protein 7C isoform X2

    3. XM_047437345.1XP_047293301.1  zinc finger and BTB domain-containing protein 7C isoform X1

    4. XM_011525864.3XP_011524166.1  zinc finger and BTB domain-containing protein 7C isoform X2

      See identical proteins and their annotated locations for XP_011524166.1

      Conserved Domains (4) summary
      smart00225
      Location:44137
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:403423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:33136
      BTB; BTB/POZ domain
      pfam13465
      Location:443468
      zf-H2C2_2; Zinc-finger double domain
    5. XM_047437348.1XP_047293304.1  zinc finger and BTB domain-containing protein 7C isoform X3

    6. XM_017025609.3XP_016881098.1  zinc finger and BTB domain-containing protein 7C isoform X4

      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
      Conserved Domains (3) summary
      COG5189
      Location:380468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    7. XM_011525865.4XP_011524167.1  zinc finger and BTB domain-containing protein 7C isoform X2

      See identical proteins and their annotated locations for XP_011524167.1

      Conserved Domains (4) summary
      smart00225
      Location:44137
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:403423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:33136
      BTB; BTB/POZ domain
      pfam13465
      Location:443468
      zf-H2C2_2; Zinc-finger double domain
    8. XM_017025606.3XP_016881095.1  zinc finger and BTB domain-containing protein 7C isoform X2

      Conserved Domains (4) summary
      smart00225
      Location:44137
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:403423
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:33136
      BTB; BTB/POZ domain
      pfam13465
      Location:443468
      zf-H2C2_2; Zinc-finger double domain
    9. XM_047437344.1XP_047293300.1  zinc finger and BTB domain-containing protein 7C isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      48217704..48603693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318277.1XP_054174252.1  zinc finger and BTB domain-containing protein 7C isoform X2

    2. XM_054318276.1XP_054174251.1  zinc finger and BTB domain-containing protein 7C isoform X2

    3. XM_054318274.1XP_054174249.1  zinc finger and BTB domain-containing protein 7C isoform X1

    4. XM_054318275.1XP_054174250.1  zinc finger and BTB domain-containing protein 7C isoform X2

    5. XM_054318280.1XP_054174255.1  zinc finger and BTB domain-containing protein 7C isoform X3

    6. XM_054318281.1XP_054174256.1  zinc finger and BTB domain-containing protein 7C isoform X4

      UniProtKB/Swiss-Prot
      A1YPR0, O73453
      UniProtKB/TrEMBL
      B2RG49
    7. XM_054318278.1XP_054174253.1  zinc finger and BTB domain-containing protein 7C isoform X2

    8. XM_054318279.1XP_054174254.1  zinc finger and BTB domain-containing protein 7C isoform X2

    9. XM_054318273.1XP_054174248.1  zinc finger and BTB domain-containing protein 7C isoform X1