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    Rrm1 ribonucleotide reductase M1 [ Mus musculus (house mouse) ]

    Gene ID: 20133, updated on 26-Sep-2022

    Summary

    Official Symbol
    Rrm1provided by MGI
    Official Full Name
    ribonucleotide reductase M1provided by MGI
    Primary source
    MGI:MGI:98180
    See related
    Ensembl:ENSMUSG00000030978 AllianceGenome:MGI:98180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RnrM1
    Summary
    Enables disordered domain specific binding activity and purine nucleotide binding activity. Contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process and protein heterotetramerization. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 64.2), liver E14.5 (RPKM 56.2) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Rrm1 in Genome Data Viewer
    Location:
    7 E3; 7 54.72 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (102090902..102118978)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102441695..102469771)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member G Neighboring gene stromal interaction molecule 1 Neighboring gene methyltransferase like 6 pseudogene Neighboring gene olfactory receptor family 55 subfamily B member 3 Neighboring gene olfactory receptor family 55 subfamily B member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in 2'-deoxyribonucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in 2'-deoxyribonucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA synthesis involved in DNA repair IC
    Inferred by Curator
    more info
    PubMed 
    involved_in deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in deoxyribonucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G0 to G1 transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterotetramerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in ribonucleoside diphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ribonucleoside diphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoside-diphosphate reductase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ribonucleoside-diphosphate reductase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoside-diphosphate reductase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of ribonucleoside-diphosphate reductase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribonucleoside-diphosphate reductase large subunit
    Names
    ribonucleoside-diphosphate reductase subunit M1
    ribonucleotide reductase large subunit
    NP_033129.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009103.3NP_033129.2  ribonucleoside-diphosphate reductase large subunit

      See identical proteins and their annotated locations for NP_033129.2

      Status: VALIDATED

      Source sequence(s)
      AC102535, AK168586
      Consensus CDS
      CCDS40049.1
      UniProtKB/Swiss-Prot
      P07742, Q91YM8
      Related
      ENSMUSP00000033283.10, ENSMUST00000033283.10
      Conserved Domains (3) summary
      cd01679
      Location:167741
      RNR_I; Class I ribonucleotide reductase
      PLN02437
      Location:1792
      PLN02437; ribonucleoside--diphosphate reductase large subunit
      pfam03477
      Location:189
      ATP-cone; ATP cone domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      102090902..102118978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)