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    Rps6ka1 ribosomal protein S6 kinase polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 20111, updated on 5-Sep-2021

    Summary

    Official Symbol
    Rps6ka1provided by MGI
    Official Full Name
    ribosomal protein S6 kinase polypeptide 1provided by MGI
    Primary source
    MGI:MGI:104558
    See related
    Ensembl:ENSMUSG00000003644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rs; Rsk; Rsk1; Rsk-1; p90S6K; p90rsk; p90Rsk1; p90-Rsk1; Mapkapk-1a; S6K-alpha-1
    Expression
    Broad expression in duodenum adult (RPKM 79.7), colon adult (RPKM 69.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rps6ka1 in Genome Data Viewer
    Location:
    4; 4 D2.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133574601..133615466, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133847290..133887797, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (133403205..133443714, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34296 Neighboring gene predicted gene, 25270 Neighboring gene predicted gene 12974 Neighboring gene predicted gene 12977 Neighboring gene predicted gene, 22523 Neighboring gene high mobility group nucleosomal binding domain 2 Neighboring gene dehydrodolichyl diphosphate synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-1
    Names
    90 kDa ribosomal protein S6 kinase 1
    MAP kinase-activated protein kinase 1a
    MAPK-activated protein kinase 1a
    MAPKAP kinase 1a
    ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1
    NP_001272434.1
    NP_001272435.1
    NP_001365809.1
    NP_033123.2
    XP_036019817.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285505.1NP_001272434.1  ribosomal protein S6 kinase alpha-1 isoform b

      See identical proteins and their annotated locations for NP_001272434.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AL837508, BC049076, BY737295
      Consensus CDS
      CCDS71488.1
      UniProtKB/Swiss-Prot
      P18653
      UniProtKB/TrEMBL
      Q810V8
      Related
      ENSMUSP00000003741.10, ENSMUST00000003741.16
      Conserved Domains (4) summary
      smart00220
      Location:62309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:66371
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:405695
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
      pfam00069
      Location:407664
      Pkinase; Protein kinase domain
    2. NM_001285506.1NP_001272435.1  ribosomal protein S6 kinase alpha-1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      BC049076, BY226173, CA547794
      Consensus CDS
      CCDS71487.1
      UniProtKB/TrEMBL
      E9PWV3, Q810V8
      Related
      ENSMUSP00000126774.3, ENSMUST00000168974.9
      Conserved Domains (4) summary
      smart00220
      Location:46304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:50366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:400690
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
      pfam00069
      Location:402659
      Pkinase; Protein kinase domain
    3. NM_001378880.1NP_001365809.1  ribosomal protein S6 kinase alpha-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL837508
      Related
      ENSMUSP00000119328.3, ENSMUST00000137486.3
      Conserved Domains (2) summary
      cd05582
      Location:72388
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:422712
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    4. NM_009097.5NP_033123.2  ribosomal protein S6 kinase alpha-1 isoform a

      See identical proteins and their annotated locations for NP_033123.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL837508, BC049076, BY737295
      Consensus CDS
      CCDS18758.2
      UniProtKB/TrEMBL
      Q505N6, Q810V8
      Related
      ENSMUSP00000101514.5, ENSMUST00000105894.11
      Conserved Domains (2) summary
      cd05582
      Location:66382
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:416706
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133574601..133615466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163924.1XP_036019817.1  ribosomal protein S6 kinase alpha-1 isoform X1

      Conserved Domains (2) summary
      cd05582
      Location:66382
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14175
      Location:416706
      STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
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