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    Rps6 ribosomal protein S6 [ Mus musculus (house mouse) ]

    Gene ID: 20104, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rps6provided by MGI
    Official Full Name
    ribosomal protein S6provided by MGI
    Primary source
    MGI:MGI:98159
    See related
    Ensembl:ENSMUSG00000028495 AllianceGenome:MGI:98159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S6R
    Summary
    A structural constituent of ribosome. Involved in glucose homeostasis. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; T cell activation; and ribosome biogenesis. Located in dendrite; perinuclear region of cytoplasm; and ribosome. Part of cytosolic small ribosomal subunit. Is expressed in several structures, including alimentary system; brain; gonad; hemolymphoid system gland; and limb. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 484.2), CNS E11.5 (RPKM 432.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Rps6 in Genome Data Viewer
    Location:
    4 C4; 4 40.69 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86772336..86775604, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86854099..86857367, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7973 Neighboring gene DENN domain containing 4C Neighboring gene predicted gene 6521 Neighboring gene STARR-seq mESC enhancer starr_10700 Neighboring gene STARR-seq mESC enhancer starr_10701 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11244 Neighboring gene STARR-seq mESC enhancer starr_10704 Neighboring gene STARR-seq mESC enhancer starr_10705 Neighboring gene alkaline ceramidase 2 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 Neighboring gene STARR-seq mESC enhancer starr_10707 Neighboring gene cadherin-2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC102571, MGC103209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell proliferation involved in immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within T cell proliferation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation-induced cell death of T cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mammalian oogenesis stage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cell cycle checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    small ribosomal subunit protein eS6
    Names
    40S ribosomal protein S6
    phosphoprotein NP33

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009096.3NP_033122.1  small ribosomal subunit protein eS6

      See identical proteins and their annotated locations for NP_033122.1

      Status: PROVISIONAL

      Source sequence(s)
      AK146952
      Consensus CDS
      CCDS18310.1
      UniProtKB/Swiss-Prot
      P62754
      UniProtKB/TrEMBL
      Q3TL53, Q5BLK1
      Related
      ENSMUSP00000099878.5, ENSMUST00000102814.5
      Conserved Domains (1) summary
      cl00931
      Location:1215
      Ribosomal_S6e; Ribosomal protein S6e

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      86772336..86775604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)