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    Rps19 ribosomal protein S19 [ Mus musculus (house mouse) ]

    Gene ID: 20085, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rps19provided by MGI
    Official Full Name
    ribosomal protein S19provided by MGI
    Primary source
    MGI:MGI:1333780
    See related
    Ensembl:ENSMUSG00000040952 AllianceGenome:MGI:1333780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dsk3
    Summary
    A structural constituent of ribosome. Acts upstream of or within Notch signaling pathway. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 234.0), liver E14.5 (RPKM 229.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rps19 in Genome Data Viewer
    Location:
    7 A3; 7 13.41 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24584013..24589236)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24884592..24889811)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Ly6/Plaur domain containing 4 Neighboring gene doublesex and mab-3 related transcription factor like family C2 Neighboring gene predicted gene, 38966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669208-25669317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669584-25669693 Neighboring gene STARR-positive B cell enhancer ABC_E10428 Neighboring gene CD79A antigen (immunoglobulin-associated alpha) Neighboring gene STARR-positive B cell enhancer ABC_E1723 Neighboring gene Rho guanine nucleotide exchange factor 1 Neighboring gene CapStarr-seq enhancers MGSCv37_chr7:25692211-25692364 and MGSCv37_chr7:25692403-25692604

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC107694

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maturation of SSU-rRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of respiratory burst involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleolus organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of respiratory burst involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    small ribosomal subunit protein eS19
    Names
    40S ribosomal protein S19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360115.2NP_001347044.2  small ribosomal subunit protein eS19 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC161441
      UniProtKB/Swiss-Prot
      Q5M9J4, Q9CZX8
    2. NM_001360116.2NP_001347045.1  small ribosomal subunit protein eS19 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC161441
      UniProtKB/TrEMBL
      Q5M9P3
      Related
      ENSMUSP00000120774.2, ENSMUST00000156372.8
      Conserved Domains (1) summary
      pfam01090
      Location:16152
      Ribosomal_S19e; Ribosomal protein S19e
    3. NM_001360118.2NP_001347047.1  small ribosomal subunit protein eS19 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC161441
      Consensus CDS
      CCDS20966.1
      UniProtKB/Swiss-Prot
      Q5M9J4, Q9CZX8
      UniProtKB/TrEMBL
      Q5M9P3
      Related
      ENSMUSP00000114949.3, ENSMUST00000153451.9
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e
    4. NM_001360119.2NP_001347048.1  small ribosomal subunit protein eS19 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC161441
      Consensus CDS
      CCDS20966.1
      UniProtKB/Swiss-Prot
      Q5M9J4, Q9CZX8
      UniProtKB/TrEMBL
      Q5M9P3
      Related
      ENSMUSP00000104068.4, ENSMUST00000108430.10
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e
    5. NM_001360125.2NP_001347054.1  small ribosomal subunit protein eS19 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC161441
      UniProtKB/TrEMBL
      Q5M9P3
      Conserved Domains (1) summary
      pfam01090
      Location:5131
      Ribosomal_S19e; Ribosomal protein S19e
    6. NM_001360128.2NP_001347057.1  small ribosomal subunit protein eS19 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (e) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC161441
      Conserved Domains (1) summary
      cl00969
      Location:571
      Ribosomal_S19e; Ribosomal protein S19e
    7. NM_023133.2NP_075622.1  small ribosomal subunit protein eS19 isoform a

      See identical proteins and their annotated locations for NP_075622.1

      Status: VALIDATED

      Source sequence(s)
      AC161441
      Consensus CDS
      CCDS20966.1
      UniProtKB/Swiss-Prot
      Q5M9J4, Q9CZX8
      UniProtKB/TrEMBL
      Q5M9P3
      Related
      ENSMUSP00000104067.2, ENSMUST00000108429.8
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e

    RNA

    1. NR_153408.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161441
      Related
      ENSMUST00000129847.8
    2. NR_153409.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161441

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24584013..24589236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)