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    Rps19 ribosomal protein S19 [ Mus musculus (house mouse) ]

    Gene ID: 20085, updated on 9-Sep-2018

    Summary

    Official Symbol
    Rps19provided by MGI
    Official Full Name
    ribosomal protein S19provided by MGI
    Primary source
    MGI:MGI:1333780
    See related
    Ensembl:ENSMUSG00000040952 Vega:OTTMUSG00000022935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dsk3
    Expression
    Ubiquitous expression in liver E14 (RPKM 234.0), liver E14.5 (RPKM 229.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rps19 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (24884376..24889806)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (25669733..25674821)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene Ly6/Plaur domain containing 4 Neighboring gene doublesex and mab-3 related transcription factor like family C2 Neighboring gene predicted gene, 38966 Neighboring gene CD79A antigen (immunoglobulin-associated alpha) Neighboring gene Rho guanine nucleotide exchange factor (GEF) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC107694

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    killing of cells of other organism ISO
    Inferred from Sequence Orthology
    more info
     
    maturation of SSU-rRNA ISO
    Inferred from Sequence Orthology
    more info
     
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
    Inferred from Sequence Orthology
    more info
     
    monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of respiratory burst involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of respiratory burst involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360115.1NP_001347044.1  40S ribosomal protein S19 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC161441
      Conserved Domains (1) summary
      pfam01090
      Location:17153
      Ribosomal_S19e; Ribosomal protein S19e
    2. NM_001360116.1NP_001347045.1  40S ribosomal protein S19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC161441, BY297002
      Conserved Domains (1) summary
      pfam01090
      Location:16152
      Ribosomal_S19e; Ribosomal protein S19e
    3. NM_001360118.1NP_001347047.1  40S ribosomal protein S19 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AC161441
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e
    4. NM_001360119.1NP_001347048.1  40S ribosomal protein S19 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AC161441
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e
    5. NM_001360125.1NP_001347054.1  40S ribosomal protein S19 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC161441, AV471616
      Conserved Domains (1) summary
      pfam01090
      Location:5131
      Ribosomal_S19e; Ribosomal protein S19e
    6. NM_001360128.1NP_001347057.1  40S ribosomal protein S19 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (e) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC161441, AV577618
      Conserved Domains (1) summary
      cl00969
      Location:571
      Ribosomal_S19e; Ribosomal protein S19e
    7. NM_023133.2NP_075622.1  40S ribosomal protein S19 isoform c

      See identical proteins and their annotated locations for NP_075622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AC161441
      Consensus CDS
      CCDS20966.1
      UniProtKB/Swiss-Prot
      Q9CZX8
      Related
      ENSMUSP00000104067.1, OTTMUSP00000026377, ENSMUST00000108429.7
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e

    RNA

    1. NR_153408.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' end and contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC161441, BU560587
    2. NR_153409.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' end and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay(NMD).
      Source sequence(s)
      AC161441

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      24884376..24889806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539680.2XP_006539743.1  40S ribosomal protein S19 isoform X1

      UniProtKB/Swiss-Prot
      Q9CZX8
      Related
      ENSMUSP00000104068.3, OTTMUSP00000026374, ENSMUST00000108430.9, OTTMUST00000055151
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e
    2. XM_006539681.2XP_006539744.1  40S ribosomal protein S19 isoform X1

      UniProtKB/Swiss-Prot
      Q9CZX8
      Related
      ENSMUSP00000114949.2, OTTMUSP00000026376, ENSMUST00000153451.8, OTTMUST00000055155
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e
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