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    Rps19 ribosomal protein S19 [ Mus musculus (house mouse) ]

    Gene ID: 20085, updated on 5-Sep-2021

    Summary

    Official Symbol
    Rps19provided by MGI
    Official Full Name
    ribosomal protein S19provided by MGI
    Primary source
    MGI:MGI:1333780
    See related
    Ensembl:ENSMUSG00000040952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dsk; Dsk3
    Expression
    Ubiquitous expression in liver E14 (RPKM 234.0), liver E14.5 (RPKM 229.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rps19 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24584017..24589236)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24884592..24889811)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (25669733..25674821)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Ly6/Plaur domain containing 4 Neighboring gene doublesex and mab-3 related transcription factor like family C2 Neighboring gene predicted gene, 38966 Neighboring gene CD79A antigen (immunoglobulin-associated alpha) Neighboring gene Rho guanine nucleotide exchange factor (GEF) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC107694

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in killing of cells of other organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maturation of SSU-rRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of respiratory burst involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleolus organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of respiratory burst involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360115.1NP_001347044.1  40S ribosomal protein S19 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC161441
      Related
      ENSMUSP00000116311.2, ENSMUST00000124035.2
      Conserved Domains (1) summary
      pfam01090
      Location:17153
      Ribosomal_S19e; Ribosomal protein S19e
    2. NM_001360116.1NP_001347045.1  40S ribosomal protein S19 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC161441, BY297002
      Related
      ENSMUSP00000120774.2, ENSMUST00000156372.8
      Conserved Domains (1) summary
      pfam01090
      Location:16152
      Ribosomal_S19e; Ribosomal protein S19e
    3. NM_001360118.1NP_001347047.1  40S ribosomal protein S19 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AC161441
      Consensus CDS
      CCDS20966.1
      Related
      ENSMUSP00000114949.3, ENSMUST00000153451.9
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e
    4. NM_001360119.1NP_001347048.1  40S ribosomal protein S19 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AC161441
      Consensus CDS
      CCDS20966.1
      Related
      ENSMUSP00000104068.4, ENSMUST00000108430.10
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e
    5. NM_001360125.1NP_001347054.1  40S ribosomal protein S19 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC161441, AV471616
      Conserved Domains (1) summary
      pfam01090
      Location:5131
      Ribosomal_S19e; Ribosomal protein S19e
    6. NM_001360128.1NP_001347057.1  40S ribosomal protein S19 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (e) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC161441, AV577618
      Conserved Domains (1) summary
      cl00969
      Location:571
      Ribosomal_S19e; Ribosomal protein S19e
    7. NM_023133.2NP_075622.1  40S ribosomal protein S19 isoform c

      See identical proteins and their annotated locations for NP_075622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
      Source sequence(s)
      AC161441
      Consensus CDS
      CCDS20966.1
      UniProtKB/Swiss-Prot
      Q9CZX8
      Related
      ENSMUSP00000104067.2, ENSMUST00000108429.8
      Conserved Domains (1) summary
      pfam01090
      Location:5141
      Ribosomal_S19e; Ribosomal protein S19e

    RNA

    1. NR_153408.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' end and contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC161441, BU560587
      Related
      ENSMUST00000129847.8
    2. NR_153409.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' end and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay(NMD).
      Source sequence(s)
      AC161441

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24584017..24589236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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