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    Polr1a polymerase (RNA) I polypeptide A [ Mus musculus (house mouse) ]

    Gene ID: 20019, updated on 23-Jun-2021

    Summary

    Official Symbol
    Polr1aprovided by MGI
    Official Full Name
    polymerase (RNA) I polypeptide Aprovided by MGI
    Primary source
    MGI:MGI:1096397
    See related
    Ensembl:ENSMUSG00000049553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mR; RPA; Rpo; 194kD; mRPA1; 194kDa; RPA194; Rpo1-4; 2900087K15Rik; 3010014K16Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 10.9), adrenal adult (RPKM 8.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Polr1a in Genome Data Viewer
    Location:
    6 C1; 6 32.21 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71886037..71956419)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71909053..71979435)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (71859047..71929354)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene inner membrane protein, mitochondrial Neighboring gene ribosomal protein L7A pseudogene Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene Neighboring gene predicted gene, 26628 Neighboring gene VISTA enhancer mm1722 Neighboring gene RIKEN cDNA 9130221F21 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to DNA-directed 5'-3' RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase I activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA-directed RNA polymerase I subunit RPA1
    Names
    DNA-directed RNA polymerase I largest subunit
    DNA-directed RNA polymerase I subunit A
    RNA polymerase 1-4 (194 kDa subunit)
    RNA polymerase I 194 kDa subunit
    RNA polymerase I subunit A1
    NP_033114.3
    XP_006505867.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009088.3NP_033114.3  DNA-directed RNA polymerase I subunit RPA1

      See identical proteins and their annotated locations for NP_033114.3

      Status: VALIDATED

      Source sequence(s)
      AK147379, AK160970, CJ260853
      Consensus CDS
      CCDS20236.1
      UniProtKB/Swiss-Prot
      O35134
      UniProtKB/TrEMBL
      Q3TU49, Q3UHI3
      Related
      ENSMUSP00000060858.9, ENSMUST00000055296.11
      Conserved Domains (4) summary
      cd02735
      Location:12061713
      RNAP_I_Rpa1_C; Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
      cd01435
      Location:161011
      RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain
      TIGR02390
      Location:101038
      RNA_pol_rpoA1; DNA-directed RNA polymerase subunit A'
      pfam04998
      Location:9651668
      RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71886037..71956419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505804.3XP_006505867.1  DNA-directed RNA polymerase I subunit RPA1 isoform X1

      Conserved Domains (2) summary
      cd01435
      Location:1509
      RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain
      pfam04998
      Location:4631165
      RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
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