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    CYP4Z1 cytochrome P450 family 4 subfamily Z member 1 [ Homo sapiens (human) ]

    Gene ID: 199974, updated on 9-Dec-2024

    Summary

    Official Symbol
    CYP4Z1provided by HGNC
    Official Full Name
    cytochrome P450 family 4 subfamily Z member 1provided by HGNC
    Primary source
    HGNC:HGNC:20583
    See related
    Ensembl:ENSG00000186160 MIM:618953; AllianceGenome:HGNC:20583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYP4A20
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See CYP4Z1 in Genome Data Viewer
    Location:
    1p33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (47055525..47118318)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46932944..46995763)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47532903..47583990)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily X member 1 Neighboring gene cytochrome P450 family 4 subfamily A member 44, pseudogene Neighboring gene uncharacterized LOC124904172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47489635-47490135 Neighboring gene tubulin alpha pseudogene 9 Neighboring gene CYP4A22 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47569786-47570506 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:47573513-47574122 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:47578681-47579223 Neighboring gene cytochrome P450 family 4 subfamily A member 22 Neighboring gene MT-ND1 pseudogene 34

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General protein information

    Preferred Names
    cytochrome P450 4Z1
    Names
    CYPIVZ1
    cytochrome P450, family 4, subfamily Z, polypeptide 1
    laurate 7-monooxygenase
    NP_835235.1
    XP_024309624.1
    XP_054190878.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007967.1 RefSeqGene

      Range
      4744..55831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_178134.3NP_835235.1  cytochrome P450 4Z1

      See identical proteins and their annotated locations for NP_835235.1

      Status: REVIEWED

      Source sequence(s)
      AL135960, AL450996
      Consensus CDS
      CCDS545.1
      UniProtKB/Swiss-Prot
      Q5VVE4, Q86W10
      Related
      ENSP00000334246.3, ENST00000334194.4
      Conserved Domains (1) summary
      pfam00067
      Location:47500
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      47055525..47118318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453856.2XP_024309624.1  cytochrome P450 4Z1 isoform X1

      Conserved Domains (1) summary
      pfam00067
      Location:9462
      p450; Cytochrome P450

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      46932944..46995763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334903.1XP_054190878.1  cytochrome P450 4Z1 isoform X1