Format

Send to:

Choose Destination
    • Showing Current items.

    Rock1 Rho-associated coiled-coil containing protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19877, updated on 5-Sep-2021

    Summary

    Official Symbol
    Rock1provided by MGI
    Official Full Name
    Rho-associated coiled-coil containing protein kinase 1provided by MGI
    Primary source
    MGI:MGI:107927
    See related
    Ensembl:ENSMUSG00000024290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Roc; Rock-I; 1110055K06Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.8), placenta adult (RPKM 6.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rock1 in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10064401..10182225, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10064401..10182251, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (10064399..10181790, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene THO complex 1 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene predicted gene, 26244 Neighboring gene high mobility group box 3 pseudogene Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Rho-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aspartic-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within apical constriction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bleb assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel diameter maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in epithelial to mesenchymal transition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glomerular visceral epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane to membrane docking ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in myoblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of connective tissue replacement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of actin filament-based process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to angiotensin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to transforming growth factor beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to transforming growth factor beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of amyloid-beta complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rho-associated protein kinase 1
    Names
    Rho-associated coiled-coil forming kinase 1
    p160 ROCK-1
    p160ROCK
    rho-associated, coiled-coil-containing protein kinase 1
    rho-associated, coiled-coil-containing protein kinase I
    NP_033097.1
    XP_006525788.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009071.2NP_033097.1  rho-associated protein kinase 1

      See identical proteins and their annotated locations for NP_033097.1

      Status: VALIDATED

      Source sequence(s)
      AA163962, AK077297, AK149793, DR754490, U58512
      Consensus CDS
      CCDS29053.2
      UniProtKB/Swiss-Prot
      P70335
      UniProtKB/TrEMBL
      Q3UE22
      Related
      ENSMUSP00000069549.6, ENSMUST00000067947.7
      Conserved Domains (7) summary
      cd11639
      Location:489554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:76338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:4221097
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:12291283
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:11191225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      pfam08912
      Location:9491014
      Rho_Binding; Rho Binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      10064401..10182225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525725.2XP_006525788.1  rho-associated protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      P70335
      Conserved Domains (5) summary
      cd11639
      Location:488553
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      COG1196
      Location:4191096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:12281282
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:11181224
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1

    RNA

    1. XR_001782350.3 RNA Sequence

    Support Center