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    Rnf7 ring finger protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 19823, updated on 5-Sep-2021

    Summary

    Official Symbol
    Rnf7provided by MGI
    Official Full Name
    ring finger protein 7provided by MGI
    Primary source
    MGI:MGI:1337096
    See related
    Ensembl:ENSMUSG00000051234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; Rbx; SAG; Rbx2
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 73.0), CNS E14 (RPKM 56.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rnf7 in Genome Data Viewer
    Location:
    9; 9 E3.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96352990..96360728, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96470937..96478675, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (96371376..96379014, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39409 Neighboring gene predicted gene, 40550 Neighboring gene predicted gene, 51656 Neighboring gene predicted gene 28729 Neighboring gene ubiquitin domain containing 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NEDD8 ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RING-box protein 2
    Names
    sensitive to apoptosis gene protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311135.1NP_001298064.1  RING-box protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the central coding region that results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC161257, AK003248, AK006703, AK011328, BF018220, BY781065
      Consensus CDS
      CCDS81056.1
      UniProtKB/Swiss-Prot
      Q9WTZ1
      UniProtKB/TrEMBL
      D3Z392
      Related
      ENSMUSP00000108581.2, ENSMUST00000071301.5
      Conserved Domains (1) summary
      cl17238
      Location:2855
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_011279.3NP_035409.1  RING-box protein 2 isoform 1

      See identical proteins and their annotated locations for NP_035409.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161257, AK003248, AK006703, AK011328, BF018220
      Consensus CDS
      CCDS40730.1
      UniProtKB/Swiss-Prot
      Q9WTZ1
      Related
      ENSMUSP00000052856.5, ENSMUST00000057500.6
      Conserved Domains (1) summary
      cd16466
      Location:47106
      RING-H2_RBX2; RING finger, H2 subclass, found in RING-box protein 2 (RBX2) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      96352990..96360728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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