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    Rnf4 ring finger protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 19822, updated on 2-Oct-2018

    Summary

    Official Symbol
    Rnf4provided by MGI
    Official Full Name
    ring finger protein 4provided by MGI
    Primary source
    MGI:MGI:1201691
    See related
    Ensembl:ENSMUSG00000029110 Vega:OTTMUSG00000043581
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SNURF; Gtrgeo8; AU018689
    Summary
    This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in placenta adult (RPKM 51.2), CNS E11.5 (RPKM 42.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rnf4 in Genome Data Viewer
    Location:
    5; 5 B2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (34336250..34353445)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (34679039..34696079)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene zinc finger, FYVE domain containing 28 Neighboring gene cilia and flagella associated protein 99 Neighboring gene predicted gene 5553 Neighboring gene family with sequence similarity 193, member A Neighboring gene TNFAIP3 interacting protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO polymer binding ISO
    Inferred from Sequence Orthology
    more info
     
    TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    progesterone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to testosterone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with PML body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF4
    Names
    E3 ubiquitin ligase RNF4
    RING-type E3 ubiquitin transferase RNF4
    NP_001291198.1
    NP_001291199.1
    NP_035408.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304269.1NP_001291198.1  E3 ubiquitin-protein ligase RNF4

      See identical proteins and their annotated locations for NP_001291198.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC104889, AK147057, BY275961, BY505719
      Consensus CDS
      CCDS57336.1
      UniProtKB/Swiss-Prot
      Q9QZS2
      Related
      ENSMUSP00000030992.5, OTTMUSP00000063856, ENSMUST00000030992.12, OTTMUST00000114417
      Conserved Domains (1) summary
      pfam13639
      Location:135181
      zf-RING_2; Ring finger domain
    2. NM_001304270.1NP_001291199.1  E3 ubiquitin-protein ligase RNF4

      See identical proteins and their annotated locations for NP_001291199.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC104889, AK019656, BY505719
      Consensus CDS
      CCDS57336.1
      UniProtKB/Swiss-Prot
      Q9QZS2
      Related
      ENSMUSP00000138411.1, OTTMUSP00000063867, ENSMUST00000182047.1, OTTMUST00000114436
      Conserved Domains (1) summary
      pfam13639
      Location:135181
      zf-RING_2; Ring finger domain
    3. NM_011278.5NP_035408.1  E3 ubiquitin-protein ligase RNF4

      See identical proteins and their annotated locations for NP_035408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC104889
      Consensus CDS
      CCDS57336.1
      UniProtKB/Swiss-Prot
      Q9QZS2
      Related
      ENSMUSP00000138555.1, OTTMUSP00000063857, ENSMUST00000182709.7, OTTMUST00000114418
      Conserved Domains (1) summary
      pfam13639
      Location:135181
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      34336250..34353445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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