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    Uri1 URI1, prefoldin-like chaperone [ Mus musculus (house mouse) ]

    Gene ID: 19777, updated on 31-Jan-2019

    Summary

    Official Symbol
    Uri1provided by MGI
    Official Full Name
    URI1, prefoldin-like chaperoneprovided by MGI
    Primary source
    MGI:MGI:1342294
    See related
    Ensembl:ENSMUSG00000030421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rmp; NNX3; C80913
    Expression
    Ubiquitous expression in testis adult (RPKM 10.9), bladder adult (RPKM 10.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Uri1 in Genome Data Viewer
    Location:
    7; 7 B3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (37959992..38023575, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (38745011..38804571, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30544 Neighboring gene zinc finger protein 536 Neighboring gene predicted gene, 30483 Neighboring gene predicted gene, 30684 Neighboring gene predicted gene, 30771 Neighboring gene cyclin E1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    unconventional prefoldin RPB5 interactor
    Names
    RNA polymerase II subunit 5-mediating protein
    RPB5-mediating protein
    protein phosphatase 1 regulatory subunit 19

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011274.5NP_035404.4  unconventional prefoldin RPB5 interactor

      See identical proteins and their annotated locations for NP_035404.4

      Status: VALIDATED

      Source sequence(s)
      AK133383, AK166566, BE633468, BY073657
      Consensus CDS
      CCDS21157.1
      UniProtKB/Swiss-Prot
      Q3TLD5
      Related
      ENSMUSP00000082646.4, ENSMUST00000085513.5
      Conserved Domains (1) summary
      cl09111
      Location:36145
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      37959992..38023575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539676.2XP_006539739.1  unconventional prefoldin RPB5 interactor isoform X1

      Related
      ENSMUSP00000145738.1, ENSMUST00000206581.1
      Conserved Domains (1) summary
      cl09111
      Location:50152
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. XM_006539677.3XP_006539740.1  unconventional prefoldin RPB5 interactor isoform X2

      Conserved Domains (1) summary
      cl09111
      Location:899
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    3. XM_006539678.3XP_006539741.1  unconventional prefoldin RPB5 interactor isoform X3

      See identical proteins and their annotated locations for XP_006539741.1

      UniProtKB/Swiss-Prot
      Q3TLD5
      Conserved Domains (1) summary
      cl09111
      Location:171
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
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