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    Rit1 Ras-like without CAAX 1 [ Mus musculus (house mouse) ]

    Gene ID: 19769, updated on 6-Sep-2021

    Summary

    Official Symbol
    Rit1provided by MGI
    Official Full Name
    Ras-like without CAAX 1provided by MGI
    Primary source
    MGI:MGI:108053
    See related
    Ensembl:ENSMUSG00000028057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R; Rit; RIBB; ROC1
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.8), heart adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rit1 in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88624151..88638355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88716842..88731048)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (88520776..88534970)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 4 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene predicted gene, 25820 Neighboring gene synaptotagmin XI Neighboring gene gon-4-like pseudogene Neighboring gene RIKEN cDNA 1500004A13 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    GTP-binding protein Rit1
    Names
    RAS-like protein expressed in many tissues
    ras-like without CAAX protein 1
    NP_001156782.1
    NP_033095.1
    XP_006501221.1
    XP_006501223.1
    XP_030108338.1
    XP_036018857.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163310.1NP_001156782.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC134246, BY284832, CX242151
      Consensus CDS
      CCDS50952.1
      UniProtKB/TrEMBL
      E9Q672
      Related
      ENSMUSP00000130464.2, ENSMUST00000172252.2
      Conserved Domains (1) summary
      cl38936
      Location:1155
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_009069.4NP_033095.1  GTP-binding protein Rit1 isoform 1

      See identical proteins and their annotated locations for NP_033095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC134246, AK005357, BY284832
      Consensus CDS
      CCDS17484.1
      UniProtKB/Swiss-Prot
      P70426
      Related
      ENSMUSP00000029692.9, ENSMUST00000029692.15
      Conserved Domains (1) summary
      cd04141
      Location:20191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

    RNA

    1. NR_028056.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore not thought to be protein-coding.
      Source sequence(s)
      AC134246, BY284832, CV562852
      Related
      ENSMUST00000170377.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88624151..88638355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501158.5XP_006501221.1  GTP-binding protein Rit1 isoform X1

      Conserved Domains (1) summary
      cd04141
      Location:74245
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
    2. XM_006501160.5XP_006501223.1  GTP-binding protein Rit1 isoform X2

      See identical proteins and their annotated locations for XP_006501223.1

      UniProtKB/Swiss-Prot
      P70426
      Conserved Domains (1) summary
      cd04141
      Location:20191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
    3. XM_030252478.2XP_030108338.1  GTP-binding protein Rit1 isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:1155
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_036162964.1XP_036018857.1  GTP-binding protein Rit1 isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:1155
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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