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    Rit1 Ras-like without CAAX 1 [ Mus musculus (house mouse) ]

    Gene ID: 19769, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rit1provided by MGI
    Official Full Name
    Ras-like without CAAX 1provided by MGI
    Primary source
    MGI:MGI:108053
    See related
    Ensembl:ENSMUSG00000028057 AllianceGenome:MGI:108053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rit; RIBB; ROC1
    Summary
    Enables GTP binding activity. Predicted to be involved in Ras protein signal transduction. Located in plasma membrane. Is expressed in Meckel's cartilage; bone; hip; liver; and rib. Used to study Noonan syndrome 8. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to human RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.8), heart adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rit1 in Genome Data Viewer
    Location:
    3 F1; 3 38.95 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88624154..88638354)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88716842..88731048)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 4 Neighboring gene STARR-seq mESC enhancer starr_08214 Neighboring gene STARR-positive B cell enhancer ABC_E2077 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88490214-88490323 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene predicted gene, 25820 Neighboring gene STARR-positive B cell enhancer ABC_E2669 Neighboring gene STARR-seq mESC enhancer starr_08216 Neighboring gene predicted gene 10253 Neighboring gene synaptotagmin XI Neighboring gene STARR-positive B cell enhancer ABC_E4551 Neighboring gene STARR-positive B cell enhancer ABC_E3444

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    GTP-binding protein Rit1
    Names
    RAS-like protein expressed in many tissues
    ras-like without CAAX protein 1
    NP_001156782.1
    NP_001390950.1
    NP_001390951.1
    NP_001390958.1
    NP_001390959.1
    NP_001390960.1
    NP_001390962.1
    NP_001390963.1
    NP_001390964.1
    NP_001390965.1
    NP_033095.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163310.2NP_001156782.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC134246
      Consensus CDS
      CCDS50952.1
      UniProtKB/TrEMBL
      E9Q672
      Related
      ENSMUSP00000130464.2, ENSMUST00000172252.2
      Conserved Domains (1) summary
      cl38936
      Location:1155
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001404021.1NP_001390950.1  GTP-binding protein Rit1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/Swiss-Prot
      P70426
    3. NM_001404022.1NP_001390951.1  GTP-binding protein Rit1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/Swiss-Prot
      P70426
    4. NM_001404029.1NP_001390958.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/TrEMBL
      E9Q672
    5. NM_001404030.1NP_001390959.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/TrEMBL
      E9Q672
    6. NM_001404031.1NP_001390960.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134246
      UniProtKB/TrEMBL
      E9Q672
    7. NM_001404033.1NP_001390962.1  GTP-binding protein Rit1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134246
    8. NM_001404034.1NP_001390963.1  GTP-binding protein Rit1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134246
      Related
      ENSMUST00000166234.2
    9. NM_001404035.1NP_001390964.1  GTP-binding protein Rit1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134246
    10. NM_001404036.1NP_001390965.1  GTP-binding protein Rit1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134246
    11. NM_009069.5NP_033095.1  GTP-binding protein Rit1 isoform 1

      See identical proteins and their annotated locations for NP_033095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC134246
      Consensus CDS
      CCDS17484.1
      UniProtKB/Swiss-Prot
      P70426
      UniProtKB/TrEMBL
      A0A1S6GWG2
      Related
      ENSMUSP00000029692.9, ENSMUST00000029692.15
      Conserved Domains (1) summary
      cd04141
      Location:20191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88624154..88638354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_028056.1: Suppressed sequence

      Description
      NR_028056.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.