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    Rit1 Ras-like without CAAX 1 [ Mus musculus (house mouse) ]

    Gene ID: 19769, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rit1provided by MGI
    Official Full Name
    Ras-like without CAAX 1provided by MGI
    Primary source
    MGI:MGI:108053
    See related
    Ensembl:ENSMUSG00000028057 Vega:OTTMUSG00000035185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rit; RIBB; ROC1
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.8), heart adult (RPKM 14.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rit1 in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (88716841..88731048)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (88520776..88534970)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 4 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene synaptotagmin XI Neighboring gene gon-4-like pseudogene Neighboring gene RIKEN cDNA 1500004A13 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    GTP-binding protein Rit1
    Names
    RAS-like protein expressed in many tissues
    ras-like without CAAX protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163310.1NP_001156782.1  GTP-binding protein Rit1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC134246, BY284832, CX242151
      Consensus CDS
      CCDS50952.1
      UniProtKB/TrEMBL
      E9Q672
      Related
      ENSMUSP00000130464.1, OTTMUSP00000049008, ENSMUST00000172252.1, OTTMUST00000089631
      Conserved Domains (2) summary
      smart00173
      Location:1149
      RAS; Ras subfamily of RAS small GTPases
      cl21455
      Location:1155
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_009069.4NP_033095.1  GTP-binding protein Rit1 isoform 1

      See identical proteins and their annotated locations for NP_033095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC134246, AK005357, BY284832
      Consensus CDS
      CCDS17484.1
      UniProtKB/Swiss-Prot
      P70426
      Related
      ENSMUSP00000029692.8, OTTMUSP00000049004, ENSMUST00000029692.14, OTTMUST00000089625
      Conserved Domains (2) summary
      smart00010
      Location:20185
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04141
      Location:20191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

    RNA

    1. NR_028056.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore not thought to be protein-coding.
      Source sequence(s)
      AC134246, BY284832, CV562852
      Related
      ENSMUST00000170377.7, OTTMUST00000089626

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      88716841..88731048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501158.3XP_006501221.1  GTP-binding protein Rit1 isoform X1

      Conserved Domains (2) summary
      smart00010
      Location:74239
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04141
      Location:74245
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
    2. XM_017319506.1XP_017174995.1  GTP-binding protein Rit1 isoform X2

      UniProtKB/TrEMBL
      A0A1S6GWG2
      Conserved Domains (1) summary
      cd04141
      Location:70241
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
    3. XM_006501160.3XP_006501223.1  GTP-binding protein Rit1 isoform X3

      See identical proteins and their annotated locations for XP_006501223.1

      UniProtKB/Swiss-Prot
      P70426
      Conserved Domains (2) summary
      smart00010
      Location:20185
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04141
      Location:20191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
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