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    Ralbp1 ralA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19765, updated on 13-Oct-2018

    Summary

    Official Symbol
    Ralbp1provided by MGI
    Official Full Name
    ralA binding protein 1provided by MGI
    Primary source
    MGI:MGI:108466
    See related
    Ensembl:ENSMUSG00000024096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rip1; RLIP76
    Expression
    Ubiquitous expression in placenta adult (RPKM 25.5), lung adult (RPKM 22.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ralbp1 in Genome Data Viewer
    Location:
    17 E1.1; 17 35.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (65848415..65885755, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (66197755..66217171, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene RAB31, member RAS oncogene family Neighboring gene protein phosphatase 4, regulatory subunit 1 Neighboring gene predicted gene, 35550 Neighboring gene twisted gastrulation BMP signaling modulator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
      Toll Like Receptor signaling, organism-specific biosystemToll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells su...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase activity, coupled to transmembrane movement of substances ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Rac GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Ral GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Ral GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Ral GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    drug transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    doxorubicin transport ISO
    Inferred from Sequence Orthology
    more info
     
    drug transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ralA-binding protein 1
    Names
    DNP-SG ATPase
    Ral-interacting protein 1
    dinitrophenyl S-glutathione ATPase

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198949.1NP_001185878.1  ralA-binding protein 1

      See identical proteins and their annotated locations for NP_001185878.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC067073, CJ146118
      Consensus CDS
      CCDS37678.1
      UniProtKB/Swiss-Prot
      Q62172
      Related
      ENSMUSP00000024905.9, ENSMUST00000024905.10
      Conserved Domains (1) summary
      cd04381
      Location:190371
      RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...
    2. NM_009067.5NP_033093.2  ralA-binding protein 1

      See identical proteins and their annotated locations for NP_033093.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC067073, CK627599
      Consensus CDS
      CCDS37678.1
      UniProtKB/Swiss-Prot
      Q62172
      Related
      ENSMUSP00000129448.2, ENSMUST00000166543.9
      Conserved Domains (1) summary
      cd04381
      Location:190371
      RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      65848415..65885755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523915.3XP_006523978.1  ralA-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cd04381
      Location:190371
      RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...
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