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    Ralgds ral guanine nucleotide dissociation stimulator [ Mus musculus (house mouse) ]

    Gene ID: 19730, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ralgdsprovided by MGI
    Official Full Name
    ral guanine nucleotide dissociation stimulatorprovided by MGI
    Primary source
    MGI:MGI:107485
    See related
    Ensembl:ENSMUSG00000026821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gn; Ra; Rg; Gnds; Rgds; mKIAA1308
    Expression
    Ubiquitous expression in testis adult (RPKM 54.6), colon adult (RPKM 48.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ralgds in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28403037..28443094)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28513089..28553082)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (28368687..28408602)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Neighboring gene VISTA enhancer mm337 Neighboring gene carboxyl ester lipase Neighboring gene general transcription factor IIIC, polypeptide 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ral guanine nucleotide dissociation stimulator
    Names
    ral guanine nucleotide exchange factor
    ralGEF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145834.1NP_001139306.1  ral guanine nucleotide dissociation stimulator isoform 4

      See identical proteins and their annotated locations for NP_001139306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site at the 5' end of an exon and differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) lacks an internal segment and has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK141959, CF537148, CF585220
      UniProtKB/TrEMBL
      Q3UQY9
      Conserved Domains (3) summary
      cd00153
      Location:724809
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:308575
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:57181
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    2. NM_001145835.1NP_001139307.1  ral guanine nucleotide dissociation stimulator isoform 1

      See identical proteins and their annotated locations for NP_001139307.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK159020, AK159754, BY346626, CF585220
      Consensus CDS
      CCDS50547.1
      UniProtKB/TrEMBL
      Q3TWC1, Q3TXZ3
      Related
      ENSMUSP00000097812.4, ENSMUST00000100241.10
      Conserved Domains (3) summary
      cd00153
      Location:791876
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:375642
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:112248
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    3. NM_001145836.1NP_001139308.1  ral guanine nucleotide dissociation stimulator isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK129328, AK159020, BY346626, CF585220
      Consensus CDS
      CCDS50548.1
      UniProtKB/TrEMBL
      A2AK33, Q3TXZ3, Q6ZPU1
      Related
      ENSMUSP00000109526.2, ENSMUST00000113893.8
      Conserved Domains (3) summary
      cd00153
      Location:779864
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:363630
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:112236
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    4. NM_009058.2NP_033084.2  ral guanine nucleotide dissociation stimulator isoform 3

      See identical proteins and their annotated locations for NP_033084.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK129328, CF537148, CF585220
      Consensus CDS
      CCDS15840.1
      UniProtKB/Swiss-Prot
      Q03385
      UniProtKB/TrEMBL
      Q6ZPU1
      Related
      ENSMUSP00000028170.9, ENSMUST00000028170.15
      Conserved Domains (3) summary
      cd00153
      Location:736821
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:320587
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:57193
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28403037..28443094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159765.1XP_036015658.1  ral guanine nucleotide dissociation stimulator isoform X7

      Conserved Domains (3) summary
      smart00147
      Location:320564
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:57193
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17209
      Location:713798
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    2. XM_030248857.2XP_030104717.1  ral guanine nucleotide dissociation stimulator isoform X8

      Conserved Domains (3) summary
      smart00147
      Location:308575
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:57181
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17209
      Location:666751
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    3. XM_006497798.5XP_006497861.1  ral guanine nucleotide dissociation stimulator isoform X3

      Conserved Domains (3) summary
      smart00147
      Location:321588
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:57194
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17209
      Location:737822
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    4. XM_006497799.5XP_006497862.1  ral guanine nucleotide dissociation stimulator isoform X9

      Conserved Domains (2) summary
      smart00147
      Location:144411
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd17209
      Location:560645
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    5. XM_006497797.5XP_006497860.1  ral guanine nucleotide dissociation stimulator isoform X4

      Conserved Domains (3) summary
      smart00147
      Location:376643
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:112249
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17209
      Location:734819
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    6. XM_036159759.1XP_036015652.1  ral guanine nucleotide dissociation stimulator isoform X2

      Conserved Domains (3) summary
      smart00147
      Location:376620
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:112249
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17209
      Location:769854
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    7. XM_030248854.2XP_030104714.1  ral guanine nucleotide dissociation stimulator isoform X5

      Conserved Domains (3) summary
      smart00147
      Location:375642
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:112248
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17209
      Location:733818
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    8. XM_030248855.2XP_030104715.1  ral guanine nucleotide dissociation stimulator isoform X6

      Conserved Domains (3) summary
      smart00147
      Location:363630
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:112236
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17209
      Location:721806
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    9. XM_006497796.4XP_006497859.1  ral guanine nucleotide dissociation stimulator isoform X1

      Conserved Domains (3) summary
      smart00147
      Location:376643
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:112249
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17209
      Location:792877
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
    10. XM_030248861.2XP_030104721.1  ral guanine nucleotide dissociation stimulator isoform X9

      Conserved Domains (2) summary
      smart00147
      Location:144411
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd17209
      Location:560645
      RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
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