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    Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 19714, updated on 9-Aug-2021

    Summary

    Official Symbol
    Rev3lprovided by MGI
    Official Full Name
    REV3 like, DNA directed polymerase zeta catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1337131
    See related
    Ensembl:ENSMUSG00000019841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R; Rev; Sez; Rev3; Sez4
    Expression
    Broad expression in CNS E18 (RPKM 11.7), whole brain E14.5 (RPKM 9.3) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rev3l in Genome Data Viewer
    Location:
    10; 10 B1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39607557..39751207)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39731561..39875211)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (39451966..39595012)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130307A14 gene Neighboring gene predicted gene 8899 Neighboring gene predicted gene, 53621 Neighboring gene predicted gene, 22105 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene major facilitator superfamily domain containing 4B4 Neighboring gene isopentenyl-diphosphate delta isomerase, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in translesion synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of zeta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA polymerase zeta catalytic subunit
    Names
    REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like
    seizure-related protein 4
    NP_035394.2
    XP_006512685.1
    XP_006512686.1
    XP_006512687.1
    XP_036011601.1
    XP_036011602.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011264.3NP_035394.2  DNA polymerase zeta catalytic subunit

      See identical proteins and their annotated locations for NP_035394.2

      Status: VALIDATED

      Source sequence(s)
      AB031049, AC118733, AC119943
      Consensus CDS
      CCDS23790.1
      UniProtKB/Swiss-Prot
      Q61493
      Related
      ENSMUSP00000019986.7, ENSMUST00000019986.13
      Conserved Domains (5) summary
      cd05778
      Location:22862524
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:25502998
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam00136
      Location:25502997
      DNA_pol_B; DNA polymerase family B
      pfam14260
      Location:30343101
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:7461132
      DUF4683; Domain of unknown function (DUF4683)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      39607557..39751207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512622.3XP_006512685.1  DNA polymerase zeta catalytic subunit isoform X1

      Conserved Domains (5) summary
      cd05778
      Location:22872525
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:25512999
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      PTZ00166
      Location:6195
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:30353102
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:7471133
      DUF4683; Domain of unknown function (DUF4683)
    2. XM_006512623.5XP_006512686.1  DNA polymerase zeta catalytic subunit isoform X2

      Conserved Domains (5) summary
      cd05778
      Location:22092447
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:24732921
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      PTZ00166
      Location:4117
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:29573024
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:6691055
      DUF4683; Domain of unknown function (DUF4683)
    3. XM_036155709.1XP_036011602.1  DNA polymerase zeta catalytic subunit isoform X4

      Conserved Domains (5) summary
      cd05778
      Location:19412179
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:22052653
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam14260
      Location:26892756
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:407787
      DUF4683; Domain of unknown function (DUF4683)
      cd22287
      Location:15251547
      REV3L_RBD; REV7 binding domain found in protein reversionless 3-like (REV3L) and similar proteins
    4. XM_036155708.1XP_036011601.1  DNA polymerase zeta catalytic subunit isoform X4

      Conserved Domains (5) summary
      cd05778
      Location:19412179
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:22052653
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam14260
      Location:26892756
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:407787
      DUF4683; Domain of unknown function (DUF4683)
      cd22287
      Location:15251547
      REV3L_RBD; REV7 binding domain found in protein reversionless 3-like (REV3L) and similar proteins
    5. XM_006512624.5XP_006512687.1  DNA polymerase zeta catalytic subunit isoform X3

      Conserved Domains (5) summary
      cd05778
      Location:22082446
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:24722920
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      PTZ00166
      Location:4117
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:29563023
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:6681054
      DUF4683; Domain of unknown function (DUF4683)

    RNA

    1. XR_004936129.1 RNA Sequence

      Related
      ENSMUST00000131186.8
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