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    PATL2 PAT1 homolog 2 [ Homo sapiens (human) ]

    Gene ID: 197135, updated on 17-Jun-2019

    Summary

    Official Symbol
    PATL2provided by HGNC
    Official Full Name
    PAT1 homolog 2provided by HGNC
    Primary source
    HGNC:HGNC:33630
    See related
    Ensembl:ENSG00000229474 MIM:614661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OOMD4; Pat1a; hPat1a
    Expression
    Broad expression in spleen (RPKM 2.6), lymph node (RPKM 2.5) and 20 other tissues See more
    Orthologs

    Genomic context

    See PATL2 in Genome Data Viewer
    Location:
    15q21.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (44665732..44711406, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44957930..44970894, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene EIF3J divergent transcript Neighboring gene eukaryotic translation initiation factor 3 subunit J Neighboring gene SPG11 vesicle trafficking associated, spatacsin Neighboring gene ring finger protein 4 pseudogene Neighboring gene microRNA 10393 Neighboring gene beta-2-microglobulin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytoplasmic mRNA processing body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cytoplasmic mRNA processing body assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein PAT1 homolog 2
    Names
    PAT1-like protein 2
    protein PAT1 homolog a
    protein associated with topoisomerase II homolog 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145112.1NP_001138584.1  protein PAT1 homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001138584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC009996, AW138454, BI835136, BI909158, DN831868, DR007980
      Consensus CDS
      CCDS45253.1
      UniProtKB/Swiss-Prot
      C9JE40
      Related
      ENSP00000416673.1, ENST00000434130.5
      Conserved Domains (1) summary
      pfam09770
      Location:263397
      PAT1; Topoisomerase II-associated protein PAT1
    2. NM_001330283.1NP_001317212.1  protein PAT1 homolog 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AW138454, BC036924
      Consensus CDS
      CCDS81873.1
      UniProtKB/TrEMBL
      H0YMQ2
      Related
      ENSP00000453695.1, ENST00000560780.1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      44665732..44711406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521340.3XP_011519642.1  protein PAT1 homolog 2 isoform X4

      See identical proteins and their annotated locations for XP_011519642.1

      Conserved Domains (1) summary
      pfam09770
      Location:263403
      PAT1; Topoisomerase II-associated protein PAT1
    2. XM_011521339.3XP_011519641.1  protein PAT1 homolog 2 isoform X4

      See identical proteins and their annotated locations for XP_011519641.1

      Conserved Domains (1) summary
      pfam09770
      Location:263403
      PAT1; Topoisomerase II-associated protein PAT1
    3. XM_011521345.3XP_011519647.1  protein PAT1 homolog 2 isoform X7

      Conserved Domains (1) summary
      pfam09770
      Location:176316
      PAT1; Topoisomerase II-associated protein PAT1
    4. XM_011521343.3XP_011519645.1  protein PAT1 homolog 2 isoform X6

      See identical proteins and their annotated locations for XP_011519645.1

      Conserved Domains (1) summary
      pfam09770
      Location:179313
      PAT1; Topoisomerase II-associated protein PAT1
    5. XM_011521338.3XP_011519640.1  protein PAT1 homolog 2 isoform X4

      See identical proteins and their annotated locations for XP_011519640.1

      Conserved Domains (1) summary
      pfam09770
      Location:263403
      PAT1; Topoisomerase II-associated protein PAT1
    6. XM_011521337.2XP_011519639.2  protein PAT1 homolog 2 isoform X2

    7. XM_011521346.2XP_011519648.2  protein PAT1 homolog 2 isoform X8

    8. XM_011521336.2XP_011519638.2  protein PAT1 homolog 2 isoform X1

    9. XM_017022000.2XP_016877489.1  protein PAT1 homolog 2 isoform X3

    10. XM_011521347.1XP_011519649.1  protein PAT1 homolog 2 isoform X9

      Conserved Domains (1) summary
      pfam09770
      Location:74214
      PAT1; Topoisomerase II-associated protein PAT1
    11. XM_011521341.1XP_011519643.1  protein PAT1 homolog 2 isoform X4

      See identical proteins and their annotated locations for XP_011519643.1

      Conserved Domains (1) summary
      pfam09770
      Location:263403
      PAT1; Topoisomerase II-associated protein PAT1
    12. XM_011521342.2XP_011519644.1  protein PAT1 homolog 2 isoform X5

      Conserved Domains (1) summary
      pfam09770
      Location:189329
      PAT1; Topoisomerase II-associated protein PAT1
    13. XM_011521344.3XP_011519646.1  protein PAT1 homolog 2 isoform X6

      See identical proteins and their annotated locations for XP_011519646.1

      Conserved Domains (1) summary
      pfam09770
      Location:179313
      PAT1; Topoisomerase II-associated protein PAT1
    14. XM_017022001.2XP_016877490.1  protein PAT1 homolog 2 isoform X7

      Conserved Domains (1) summary
      pfam09770
      Location:176316
      PAT1; Topoisomerase II-associated protein PAT1
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