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    Dpf2 D4, zinc and double PHD fingers family 2 [ Mus musculus (house mouse) ]

    Gene ID: 19708, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dpf2provided by MGI
    Official Full Name
    D4, zinc and double PHD fingers family 2provided by MGI
    Primary source
    MGI:MGI:109529
    See related
    Ensembl:ENSMUSG00000024826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Req; BAF45D; ubi-d4; 2210010M07Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 38.7), limb E14.5 (RPKM 38.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dpf2 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (5896516..5912871, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5897135..5912866, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 45 Neighboring gene tigger transposable element derived 3 Neighboring gene predicted gene, 42067 Neighboring gene CDC42 effector protein (Rho GTPase binding) 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    H3K9me3 modified histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myeloid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nBAF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger protein ubi-d4
    Names
    BRG1-associated factor 45D
    apoptosis response zinc finger protein
    neuro-d4/requiem
    protein requiem

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291078.1NP_001278007.1  zinc finger protein ubi-d4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC142098, AK004812, BB839618, BY294588, CX207082
      Consensus CDS
      CCDS70920.1
      UniProtKB/Swiss-Prot
      Q61103
      UniProtKB/TrEMBL
      D3Z5N6
      Related
      ENSMUSP00000113465.1, ENSMUST00000118623.1
      Conserved Domains (3) summary
      cd15530
      Location:343388
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15691
      Location:286341
      PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
      pfam14051
      Location:1379
      Requiem_N; N-terminal domain of DPF2/REQ
    2. NM_011262.5NP_035392.1  zinc finger protein ubi-d4 isoform 2

      See identical proteins and their annotated locations for NP_035392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC142098, AK004812, BB839618, BY294588
      Consensus CDS
      CCDS37892.1
      UniProtKB/Swiss-Prot
      Q61103
      Related
      ENSMUSP00000120125.1, ENSMUST00000136983.7
      Conserved Domains (3) summary
      cd15530
      Location:329374
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15691
      Location:272327
      PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
      pfam14051
      Location:1379
      Requiem_N; N-terminal domain of DPF2/REQ

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      5896516..5912871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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