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    Dpf2 D4, zinc and double PHD fingers family 2 [ Mus musculus (house mouse) ]

    Gene ID: 19708, updated on 24-Aug-2021

    Summary

    Official Symbol
    Dpf2provided by MGI
    Official Full Name
    D4, zinc and double PHD fingers family 2provided by MGI
    Primary source
    MGI:MGI:109529
    See related
    Ensembl:ENSMUSG00000024826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Re; Req; requi; ubi-d; BAF45D; ubi-d4; 2210010M07Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 38.7), limb E14.5 (RPKM 38.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dpf2 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5946544..5962899, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5896516..5912871, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5897135..5912866, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 45 Neighboring gene tigger transposable element derived 3 Neighboring gene predicted gene, 42067 Neighboring gene CDC42 effector protein (Rho GTPase binding) 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables H3K9me3 modified histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myeloid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF superfamily-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nBAF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger protein ubi-d4
    Names
    BRG1-associated factor 45D
    apoptosis response zinc finger protein
    neuro-d4/requiem
    protein requiem

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291078.1NP_001278007.1  zinc finger protein ubi-d4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC142098, AK004812, BB839618, BY294588, CX207082
      Consensus CDS
      CCDS70920.1
      UniProtKB/Swiss-Prot
      Q61103
      UniProtKB/TrEMBL
      D3Z5N6
      Related
      ENSMUSP00000113465.2, ENSMUST00000118623.2
      Conserved Domains (3) summary
      cd15530
      Location:343388
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15691
      Location:286341
      PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
      pfam14051
      Location:1379
      Requiem_N; N-terminal domain of DPF2/REQ
    2. NM_011262.5NP_035392.1  zinc finger protein ubi-d4 isoform 2

      See identical proteins and their annotated locations for NP_035392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC142098, AK004812, BB839618, BY294588
      Consensus CDS
      CCDS37892.1
      UniProtKB/Swiss-Prot
      Q61103
      Related
      ENSMUSP00000120125.2, ENSMUST00000136983.8
      Conserved Domains (3) summary
      cd15530
      Location:329374
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15691
      Location:272327
      PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
      pfam14051
      Location:1379
      Requiem_N; N-terminal domain of DPF2/REQ

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5946544..5962899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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