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    Rdx radixin [ Mus musculus (house mouse) ]

    Gene ID: 19684, updated on 26-Sep-2022

    Summary

    Official Symbol
    Rdxprovided by MGI
    Official Full Name
    radixinprovided by MGI
    Primary source
    MGI:MGI:97887
    See related
    Ensembl:ENSMUSG00000032050 AllianceGenome:MGI:97887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein domain specific binding activity. Involved in cellular response to thyroid hormone stimulus; establishment of protein localization; and positive regulation of G1/S transition of mitotic cell cycle. Acts upstream of or within apical protein localization and microvillus assembly. Located in several cellular components, including lamellipodium; microvillus; and ruffle. Colocalizes with plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Used to study Dubin-Johnson syndrome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.7), placenta adult (RPKM 29.6) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Rdx in Genome Data Viewer
    Location:
    9; 9 A5.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (51958450..52000038)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (52047150..52088738)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933407I05 gene Neighboring gene predicted gene 6980 Neighboring gene ferredoxin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene zinc finger CCCH type containing 12C Neighboring gene microRNA 6244 Neighboring gene predicted gene, 25562

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apical protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to thyroid hormone stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to thyroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of adherens junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein localization to early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of organelle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of organelle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell tip ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104616.1NP_001098086.1  radixin isoform a

      See identical proteins and their annotated locations for NP_001098086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AK162204, BE994963, DV662898
      Consensus CDS
      CCDS40634.1
      UniProtKB/Swiss-Prot
      P26043, Q9QW27
      UniProtKB/TrEMBL
      A0A6P5QBZ5
      Related
      ENSMUSP00000128249.2, ENSMUST00000163153.9
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family
    2. NM_001104617.1NP_001098087.1  radixin isoform b

      See identical proteins and their annotated locations for NP_001098087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' coding exons and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK016711, BC053417, BY739389
      Consensus CDS
      CCDS52793.1
      UniProtKB/TrEMBL
      Q7TSG6
      Related
      ENSMUSP00000055303.10, ENSMUST00000061352.11
      Conserved Domains (4) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:91206
      FERM_M; FERM central domain
      pfam09379
      Location:971
      FERM_N; FERM N-terminal domain
    3. NM_009041.3NP_033067.2  radixin isoform a

      See identical proteins and their annotated locations for NP_033067.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform a). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK162204, AK168449, BE994963, BY739389
      Consensus CDS
      CCDS40634.1
      UniProtKB/Swiss-Prot
      P26043, Q9QW27
      UniProtKB/TrEMBL
      A0A6P5QBZ5, Q3TH46
      Related
      ENSMUSP00000000590.9, ENSMUST00000000590.16
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      51958450..52000038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)