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    Rdx radixin [ Mus musculus (house mouse) ]

    Gene ID: 19684, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rdxprovided by MGI
    Official Full Name
    radixinprovided by MGI
    Primary source
    MGI:MGI:97887
    See related
    Ensembl:ENSMUSG00000032050 Vega:OTTMUSG00000063089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA516625
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.7), placenta adult (RPKM 29.6) and 23 other tissues See more
    Orthologs

    Genomic context

    See Rdx in Genome Data Viewer
    Location:
    9; 9 A5.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (52047150..52088738)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (51855255..51896843)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933407I05 gene Neighboring gene predicted gene 6980 Neighboring gene ferredoxin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 33614 Neighboring gene zinc finger CCCH type containing 12C Neighboring gene microRNA 6244 Neighboring gene predicted gene, 29692

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apical protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to thyroid hormone stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of adherens junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of organelle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell tip ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104616.1NP_001098086.1  radixin isoform a

      See identical proteins and their annotated locations for NP_001098086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AK162204, BE994963, DV662898
      Consensus CDS
      CCDS40634.1
      UniProtKB/Swiss-Prot
      P26043
      Related
      ENSMUSP00000128249.1, OTTMUSP00000079474, ENSMUST00000163153.8, OTTMUST00000153558
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family
    2. NM_001104617.1NP_001098087.1  radixin isoform b

      See identical proteins and their annotated locations for NP_001098087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' coding exons and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK016711, BC053417, BY739389
      Consensus CDS
      CCDS52793.1
      UniProtKB/TrEMBL
      Q7TSG6
      Related
      ENSMUSP00000055303.9, OTTMUSP00000079476, ENSMUST00000061352.10, OTTMUST00000153560
      Conserved Domains (4) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:91206
      FERM_M; FERM central domain
      pfam09379
      Location:971
      FERM_N; FERM N-terminal domain
    3. NM_009041.3NP_033067.2  radixin isoform a

      See identical proteins and their annotated locations for NP_033067.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform a). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK162204, AK168449, BE994963, BY739389
      Consensus CDS
      CCDS40634.1
      UniProtKB/Swiss-Prot
      P26043
      UniProtKB/TrEMBL
      Q3TH46
      Related
      ENSMUSP00000000590.8, OTTMUSP00000079475, ENSMUST00000000590.15, OTTMUST00000153559
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      52047150..52088738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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