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    Rbbp4 retinoblastoma binding protein 4, chromatin remodeling factor [ Mus musculus (house mouse) ]

    Gene ID: 19646, updated on 11-Sep-2021

    Summary

    Official Symbol
    Rbbp4provided by MGI
    Official Full Name
    retinoblastoma binding protein 4, chromatin remodeling factorprovided by MGI
    Primary source
    MGI:MGI:1194912
    See related
    Ensembl:ENSMUSG00000057236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RBA; RBAP48; mRbAp48
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 70.9), liver E14 (RPKM 42.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Rbbp4 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129200893..129229163, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129307100..129335370, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (128984344..129012614, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tyrosyl-tRNA synthetase Neighboring gene expressed sequence C77080 Neighboring gene predicted gene 12976 Neighboring gene syncoilin Neighboring gene zinc finger and BTB domain containing 8 opposite strand Neighboring gene zinc finger and BTB domain containing 8a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication-dependent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication-independent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CAF-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NURF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NuRD complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone-binding protein RBBP4
    Names
    CAF-1 p48 subunit
    CAF-1 subunit C
    CAF-I 48 kDa subunit
    CAF-I p48
    RBBP-4
    chromatin assembly factor 1 subunit C
    chromatin assembly factor I p48 subunit
    nucleosome-remodeling factor subunit RBAP48
    retinoblastoma-binding protein 4
    retinoblastoma-binding protein p48

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009030.3NP_033056.2  histone-binding protein RBBP4

      See identical proteins and their annotated locations for NP_033056.2

      Status: VALIDATED

      Source sequence(s)
      AL607123
      Consensus CDS
      CCDS18688.1
      UniProtKB/Swiss-Prot
      Q60972
      Related
      ENSMUSP00000099658.4, ENSMUST00000102598.4
      Conserved Domains (3) summary
      sd00039
      Location:128175
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:1988
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:122403
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129200893..129229163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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