Format

Send to:

Choose Destination
    • Showing Current items.

    AMN1 antagonist of mitotic exit network 1 homolog [ Homo sapiens (human) ]

    Gene ID: 196394, updated on 23-Nov-2021

    Summary

    Official Symbol
    AMN1provided by HGNC
    Official Full Name
    antagonist of mitotic exit network 1 homologprovided by HGNC
    Primary source
    HGNC:HGNC:27281
    See related
    Ensembl:ENSG00000151743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 7.2), brain (RPKM 4.4) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AMN1 in Genome Data Viewer
    Location:
    12p11.21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (31671137..31729174, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31824071..31882108, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene DENND5B antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 50 Neighboring gene adenylate kinase 4 pseudogene 3 Neighboring gene electron transfer flavoprotein subunit beta lysine methyltransferase Neighboring gene uncharacterized LOC105369722 Neighboring gene stathmin 1 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr12.953 Neighboring gene uncharacterized LOC105369724 Neighboring gene Sharpr-MPRA regulatory region 4305

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    Associated conditions

    Description Tests
    Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113402.2NP_001106873.1  protein AMN1 homolog isoform 1

      See identical proteins and their annotated locations for NP_001106873.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC045831, BC067906
      Consensus CDS
      CCDS44858.1
      UniProtKB/Swiss-Prot
      Q8IY45
      Related
      ENSP00000281471.6, ENST00000281471.11
      Conserved Domains (2) summary
      cd09293
      Location:37257
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:6386
      LRR_AMN1; leucine-rich repeat [structural motif]
    2. NM_001278411.2NP_001265340.1  protein AMN1 homolog isoform 2

      See identical proteins and their annotated locations for NP_001265340.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site, which results in a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform 2.
      Source sequence(s)
      BC037897, BC067906, DC325581, DC394802
      Consensus CDS
      CCDS61089.1
      UniProtKB/Swiss-Prot
      Q8IY45
      Related
      ENSP00000438990.1, ENST00000535408.5
      Conserved Domains (2) summary
      cd09293
      Location:19239
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:4568
      LRR_AMN1; leucine-rich repeat [structural motif]
    3. NM_001278412.2NP_001265341.1  protein AMN1 homolog isoform 2

      See identical proteins and their annotated locations for NP_001265341.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has two additional exons in the 5' region, which results in a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform 2.
      Source sequence(s)
      AK123033, AK302112, BC037897, BC067906
      Consensus CDS
      CCDS61089.1
      UniProtKB/Swiss-Prot
      Q8IY45
      Related
      ENSP00000440967.1, ENST00000536761.5
      Conserved Domains (2) summary
      cd09293
      Location:19239
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:4568
      LRR_AMN1; leucine-rich repeat [structural motif]

    RNA

    1. NR_103522.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has alternate exons in the 5' region and an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK123033, AK311249, BC037897, BC067906
    2. NR_103523.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK123033, AK311214, BC037897, BC067906, DC394802

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      31671137..31729174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018965.2XP_016874454.1  protein AMN1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8IY45
      Conserved Domains (2) summary
      cd09293
      Location:19239
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:4568
      LRR_AMN1; leucine-rich repeat [structural motif]
    2. XM_017018963.2XP_016874452.1  protein AMN1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8IY45
      Conserved Domains (2) summary
      cd09293
      Location:19239
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:4568
      LRR_AMN1; leucine-rich repeat [structural motif]
    3. XM_017018964.1XP_016874453.1  protein AMN1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8IY45
      Conserved Domains (2) summary
      cd09293
      Location:19239
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:4568
      LRR_AMN1; leucine-rich repeat [structural motif]
    4. XM_006719054.3XP_006719117.1  protein AMN1 homolog isoform X3

      Conserved Domains (2) summary
      cd09293
      Location:9208
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:1437
      LRR_AMN1; leucine-rich repeat [structural motif]
    Support Center