U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    EGR3 early growth response 3 [ Homo sapiens (human) ]

    Gene ID: 1960, updated on 2-Nov-2024

    Summary

    Official Symbol
    EGR3provided by HGNC
    Official Full Name
    early growth response 3provided by HGNC
    Primary source
    HGNC:HGNC:3240
    See related
    Ensembl:ENSG00000179388 MIM:602419; AllianceGenome:HGNC:3240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EGR-3; PILOT
    Summary
    This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
    Expression
    Broad expression in gall bladder (RPKM 18.5), brain (RPKM 16.1) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EGR3 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22687659..22693480, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22961911..22967732, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22545172..22550993, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986876 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22462104-22462604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19003 Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22483969-22484602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22485870-22486503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22486504-22487136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22488646-22489180 Neighboring gene bridging integrator 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22489181-22489715 Neighboring gene BIN3 intronic transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22515470-22516064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22516065-22516659 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22526357-22526986 Neighboring gene CRISPRi-validated cis-regulatory element chr8.740 Neighboring gene uncharacterized LOC107986924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22547791-22548696 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22549417-22549612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19006 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22551019-22551182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22551227-22551872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19008 Neighboring gene uncharacterized LOC105379321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19010 Neighboring gene uncharacterized LOC107986926

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of early growth response 3 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    tat HIV-1 Tat (through amino acids 30-40) binds to Egr-3 and synergizes with this protein to super induce the FasL promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138484

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to fibroblast growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle organ development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peripheral nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    early growth response protein 3
    Names
    zinc finger protein pilot

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199880.2NP_001186809.1  early growth response protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001186809.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) initiates from a distinct promoter and has a different 5' end, compared to variant (1). It encodes an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC105046, AK294968, AK295134, N66802, S40832, X63741
      Consensus CDS
      CCDS56528.1
      UniProtKB/Swiss-Prot
      Q06889
      UniProtKB/TrEMBL
      B4DH80
      Related
      ENSP00000430310.1, ENST00000522910.1
      Conserved Domains (2) summary
      COG5048
      Location:265338
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001199881.2NP_001186810.1  early growth response protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001186810.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) initiates from a distinct promoter and has a different 5' end, compared to variant (1). It encodes an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC105046, AK294968, DC333411, N66802, S40832, X63741
      UniProtKB/TrEMBL
      B4DH80
      Conserved Domains (4) summary
      COG5048
      Location:249305
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221245
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265290
      zf-H2C2_2; Zinc-finger double domain
    3. NM_004430.3NP_004421.2  early growth response protein 3 isoform 1

      See identical proteins and their annotated locations for NP_004421.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC105046, N66802, S40832, X63741
      Consensus CDS
      CCDS6033.1
      UniProtKB/Swiss-Prot
      A8K8U9, B4DHJ5, E7EW38, Q06889, Q2M3W2
      Related
      ENSP00000318057.2, ENST00000317216.3
      Conserved Domains (3) summary
      sd00017
      Location:277299
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:275299
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:319344
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      22687659..22693480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544429.3XP_011542731.2  early growth response protein 3 isoform X2

    2. XM_005273425.4XP_005273482.1  early growth response protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005273482.1

      Conserved Domains (5) summary
      COG5048
      Location:358431
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332354
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:330354
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:142202
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:374399
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      22961911..22967732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359947.1XP_054215922.1  early growth response protein 3 isoform X3

    2. XM_054359946.1XP_054215921.1  early growth response protein 3 isoform X1