Format

Send to:

Choose Destination
    • Showing Current items.

    Klf11 Kruppel-like factor 11 [ Mus musculus (house mouse) ]

    Gene ID: 194655, updated on 2-Oct-2018

    Summary

    Official Symbol
    Klf11provided by MGI
    Official Full Name
    Kruppel-like factor 11provided by MGI
    Primary source
    MGI:MGI:2653368
    See related
    Ensembl:ENSMUSG00000020653 Vega:OTTMUSG00000027554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tieg2; Tieg3; Tieg2b; 9830142A17; D12Ertd427e
    Expression
    Ubiquitous expression in lung adult (RPKM 9.8), ovary adult (RPKM 9.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Klf11 in Genome Data Viewer
    Location:
    12 A1.3; 12 8.49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (24651371..24662782)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (25336236..25347647)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene grainyhead like transcription factor 1 Neighboring gene cytochrome c oxidase subunit VIIa polypeptide 2-like pseudogene Neighboring gene cystin 1 Neighboring gene predicted gene, 36129 Neighboring gene ribonucleotide reductase M2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    NOT hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription involved in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    Krueppel-like factor 11
    Names
    TGFB inducible early growth response 2
    TGFB inducible early growth response 3
    TGFB-inducible early growth response protein 2b
    TGFB-inducible early growth response protein 3
    TIEG-3
    klf11
    transforming growth factor-beta-inducible early growth response protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178357.3NP_848134.1  Krueppel-like factor 11

      See identical proteins and their annotated locations for NP_848134.1

      Status: VALIDATED

      Source sequence(s)
      AK038397, DV654709
      Consensus CDS
      CCDS25842.1
      UniProtKB/Swiss-Prot
      Q8K1S5
      Related
      ENSMUSP00000020982.5, OTTMUSP00000034445, ENSMUST00000020982.6, OTTMUST00000068231
      Conserved Domains (4) summary
      COG5048
      Location:382439
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:389408
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:444466
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:430453
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      24651371..24662782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center