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    Mical3 microtubule associated monooxygenase, calponin and LIM domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 194401, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mical3provided by MGI
    Official Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing 3provided by MGI
    Primary source
    MGI:MGI:2442733
    See related
    Ensembl:ENSMUSG00000051586 Vega:OTTMUSG00000023537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mical-3; mKIAA1364; C130040D16Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 14.5), ovary adult (RPKM 11.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mical3 in Genome Data Viewer
    Location:
    6; 6 F1
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (120931546..121173757, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (120957258..121031627, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene BCL2-like 13 (apoptosis facilitator) Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene BH3 interacting domain death agonist Neighboring gene predicted gene 9878 Neighboring gene predicted gene 4651 Neighboring gene multiple inositol polyphosphate histidine phosphatase 1, pseudogene Neighboring gene predicted gene, 30842 Neighboring gene peroxisomal biogenesis factor 26 Neighboring gene predicted gene, 38651

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0819

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    [F-actin]-monooxygenase MICAL3; protein-methionine sulfoxide oxidase MICAL3
    Names
    [F-actin]-methionine sulfoxide oxidase MICAL3
    flavoprotein oxidoreductase MICAL3
    molecule interacting with CasL protein 3
    NP_001257404.1
    NP_700445.2
    XP_006505863.1
    XP_011239560.1
    XP_017176955.1
    XP_017176956.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270475.1NP_001257404.1  [F-actin]-monooxygenase MICAL3 isoform 1

      See identical proteins and their annotated locations for NP_001257404.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI845760, AK035932, AK048201, AK147803, BC043122, BC090651, BM899307, CJ105256
      Consensus CDS
      CCDS85152.1
      UniProtKB/Swiss-Prot
      Q8CJ19
      UniProtKB/TrEMBL
      Q5CZW8
      Related
      ENSMUSP00000146544.1, OTTMUSP00000076298, ENSMUST00000207889.1, OTTMUST00000146581
      Conserved Domains (5) summary
      cd09439
      Location:764818
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:524619
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:18411979
      DUF3585; Protein of unknown function (DUF3585)
      pfam13450
      Location:91119
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    2. NM_153396.3NP_700445.2  [F-actin]-monooxygenase MICAL3 isoform 2

      See identical proteins and their annotated locations for NP_700445.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks several 3' exons and includes an alternate 3' exon. The encoded isoform (2) has a distinct and shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC079443, AK132669, BX630380
      Consensus CDS
      CCDS20487.1
      UniProtKB/Swiss-Prot
      Q8CJ19
      Related
      ENSMUSP00000076402.5, OTTMUSP00000073536, ENSMUST00000077159.7, OTTMUST00000140246
      Conserved Domains (4) summary
      pfam00307
      Location:524619
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87274
      FAD_binding_3; FAD binding domain
      pfam13450
      Location:91119
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl02475
      Location:764809
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RNA

    1. NR_138097.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079443, AK132669

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      120931546..121173757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241258.2XP_011239560.1  protein-methionine sulfoxide oxidase MICAL3 isoform X1

      See identical proteins and their annotated locations for XP_011239560.1

      Conserved Domains (5) summary
      cd09439
      Location:916970
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:524619
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:20612238
      DUF3585; Protein of unknown function (DUF3585)
      pfam13450
      Location:91119
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    2. XM_006505800.2XP_006505863.1  protein-methionine sulfoxide oxidase MICAL3 isoform X2

      See identical proteins and their annotated locations for XP_006505863.1

      UniProtKB/Swiss-Prot
      Q8CJ19
      Conserved Domains (5) summary
      cd09439
      Location:764818
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:524619
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87274
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:18411979
      DUF3585; Protein of unknown function (DUF3585)
      pfam13450
      Location:91119
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    3. XM_017321466.1XP_017176955.1  protein-methionine sulfoxide oxidase MICAL3 isoform X3

      Conserved Domains (4) summary
      pfam00307
      Location:524619
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87274
      FAD_binding_3; FAD binding domain
      pfam13450
      Location:91119
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl02475
      Location:916961
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    4. XM_017321467.1XP_017176956.1  protein-methionine sulfoxide oxidase MICAL3 isoform X4

      Conserved Domains (4) summary
      pfam00307
      Location:524619
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87274
      FAD_binding_3; FAD binding domain
      pfam13450
      Location:91119
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl02475
      Location:792837
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_039382.4 Reference GRCm38.p4 129S1/SvImJ

      Range
      556177..630123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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