Format

Send to:

Choose Destination
    • Showing Current items.

    Tet3 tet methylcytosine dioxygenase 3 [ Mus musculus (house mouse) ]

    Gene ID: 194388, updated on 26-Jul-2021

    Summary

    Official Symbol
    Tet3provided by MGI
    Official Full Name
    tet methylcytosine dioxygenase 3provided by MGI
    Primary source
    MGI:MGI:2446229
    See related
    Ensembl:ENSMUSG00000034832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BC037432; B430006D22Rik; D230004J03Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.4), thymus adult (RPKM 8.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tet3 in Genome Data Viewer
    Location:
    6; 6 C3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83339355..83434190, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83362373..83457208, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (83312367..83391672, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 1A Neighboring gene bolA-like 3 (E. coli) Neighboring gene microRNA 6374 Neighboring gene RIKEN cDNA B230319C09 gene Neighboring gene deoxyguanosine kinase Neighboring gene actin, gamma 2, smooth muscle, enteric

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylcytosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables methylcytosine dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylcytosine dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 5-methylcytosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within DNA demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA demethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA demethylation of male pronucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H3-K4 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxidative demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in female pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    methylcytosine dioxygenase TET3
    Names
    probable methylcytosine dioxygenase TET3
    tet oncogene family member 3
    NP_001334242.1
    NP_898961.2
    XP_006505838.1
    XP_006505839.1
    XP_006505840.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347313.1NP_001334242.1  methylcytosine dioxygenase TET3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090648, AC159713
      Consensus CDS
      CCDS85071.1
      UniProtKB/Swiss-Prot
      Q8BG87
      Related
      ENSMUSP00000139630.2, ENSMUST00000186548.7
      Conserved Domains (4) summary
      PHA03247
      Location:297760
      PHA03247; large tegument protein UL36; Provisional
      pfam02008
      Location:5089
      zf-CXXC; CXXC zinc finger domain
      cd18897
      Location:8361160
      TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins
      cl40427
      Location:16121774
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
    2. NM_183138.2NP_898961.2  methylcytosine dioxygenase TET3 isoform 2

      See identical proteins and their annotated locations for NP_898961.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple exons in the coding region, and uses an in-frame downstream start codon, compared to variant 1. Variant 2 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090648, AC159713
      Consensus CDS
      CCDS51820.1
      UniProtKB/Swiss-Prot
      Q8BG87
      Related
      ENSMUSP00000087049.5, ENSMUST00000089622.11
      Conserved Domains (1) summary
      pfam12851
      Location:858985
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83339355..83434190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505776.4XP_006505839.1  methylcytosine dioxygenase TET3 isoform X1

      See identical proteins and their annotated locations for XP_006505839.1

      UniProtKB/Swiss-Prot
      Q8BG87
      Conserved Domains (4) summary
      PHA03247
      Location:297760
      PHA03247; large tegument protein UL36; Provisional
      pfam02008
      Location:5089
      zf-CXXC; CXXC zinc finger domain
      cd18897
      Location:8361160
      TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins
      cl40427
      Location:16121774
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
    2. XM_006505775.4XP_006505838.1  methylcytosine dioxygenase TET3 isoform X1

      See identical proteins and their annotated locations for XP_006505838.1

      UniProtKB/Swiss-Prot
      Q8BG87
      Conserved Domains (4) summary
      PHA03247
      Location:297760
      PHA03247; large tegument protein UL36; Provisional
      pfam02008
      Location:5089
      zf-CXXC; CXXC zinc finger domain
      cd18897
      Location:8361160
      TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins
      cl40427
      Location:16121774
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
    3. XM_006505777.4XP_006505840.1  methylcytosine dioxygenase TET3 isoform X2

      See identical proteins and their annotated locations for XP_006505840.1

      UniProtKB/TrEMBL
      K9JH93
      Conserved Domains (4) summary
      PHA03247
      Location:278741
      PHA03247; large tegument protein UL36; Provisional
      pfam02008
      Location:5089
      zf-CXXC; CXXC zinc finger domain
      cd18897
      Location:8171141
      TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins
      cl40427
      Location:15931755
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
    Support Center