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    EFNA2 ephrin A2 [ Homo sapiens (human) ]

    Gene ID: 1943, updated on 13-Mar-2020

    Summary

    Official Symbol
    EFNA2provided by HGNC
    Official Full Name
    ephrin A2provided by HGNC
    Primary source
    HGNC:HGNC:3222
    See related
    Ensembl:ENSG00000099617 MIM:602756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ELF-1; EPLG6; LERK6; HEK7-L; LERK-6
    Summary
    This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 3.0), colon (RPKM 2.7) and 5 other tissues See more
    Orthologs

    Genomic context

    See EFNA2 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1282817..1301431)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1286153..1301430)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CIRBP antisense RNA 1 Neighboring gene cold inducible RNA binding protein Neighboring gene family with sequence similarity 174 member C Neighboring gene ribosomal protein S15 pseudogene 9 Neighboring gene PWWP domain containing 3A, DNA repair factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bone remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bone remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    olfactory bulb development IEA
    Inferred from Electronic Annotation
    more info
     
    osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ephrin-A2
    Names
    HEK7 ligand
    eph-related receptor tyrosine kinase ligand 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405.4NP_001396.2  ephrin-A2 precursor

      See identical proteins and their annotated locations for NP_001396.2

      Status: REVIEWED

      Source sequence(s)
      AC004258
      Consensus CDS
      CCDS12061.1
      UniProtKB/Swiss-Prot
      O43921
      Related
      ENSP00000215368.1, ENST00000215368.4
      Conserved Domains (1) summary
      cd10425
      Location:35171
      Ephrin-A_Ectodomain; Ectodomain of Ephrin A

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      1282817..1301431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026449.1XP_016881938.1  ephrin-A2 isoform X1

    2. XM_017026450.1XP_016881939.1  ephrin-A2 isoform X2

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