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    Rad52 RAD52 homolog, DNA repair protein [ Mus musculus (house mouse) ]

    Gene ID: 19365, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rad52provided by MGI
    Official Full Name
    RAD52 homolog, DNA repair proteinprovided by MGI
    Primary source
    MGI:MGI:101949
    See related
    Ensembl:ENSMUSG00000030166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rad52yh
    Expression
    Ubiquitous expression in thymus adult (RPKM 3.7), limb E14.5 (RPKM 3.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rad52 in Genome Data Viewer
    Location:
    6 F1; 6 56.86 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119878781..119899789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119901722..119922827)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (119852716..119872841)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene family with sequence similarity 76, member A pseudogene Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene microRNA 706 Neighboring gene ninjurin 2 Neighboring gene predicted gene, 25327

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing involved in repair via single-strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA double-strand break processing involved in repair via single-strand annealing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in DNA recombinase assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA recombination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair via single-strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA repair protein RAD52 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166381.1NP_001159853.1  DNA repair protein RAD52 homolog isoform 1

      See identical proteins and their annotated locations for NP_001159853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC117667, AK080702, BE852444, CJ057181
      Consensus CDS
      CCDS51887.1
      UniProtKB/Swiss-Prot
      P43352
      Related
      ENSMUSP00000125502.2, ENSMUST00000162461.7
      Conserved Domains (1) summary
      TIGR00607
      Location:39200
      rad52; recombination protein rad52
    2. NM_001166382.1NP_001159854.1  DNA repair protein RAD52 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC117667, AK080702, BE852444, CJ057181
      Conserved Domains (1) summary
      TIGR00607
      Location:39200
      rad52; recombination protein rad52
    3. NM_001166383.1NP_001159855.1  DNA repair protein RAD52 homolog isoform 2

      See identical proteins and their annotated locations for NP_001159855.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC117667, AK080702, CJ057181
      UniProtKB/TrEMBL
      Q8VEE2
      Related
      ENSMUST00000161816.8
      Conserved Domains (1) summary
      TIGR00607
      Location:39200
      rad52; recombination protein rad52
    4. NM_011236.2NP_035366.2  DNA repair protein RAD52 homolog isoform 4

      See identical proteins and their annotated locations for NP_035366.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AC117667, AK080702, BE852444, CJ057181
      Consensus CDS
      CCDS20477.1
      UniProtKB/TrEMBL
      G5E879
      Related
      ENSMUSP00000032269.7, ENSMUST00000032269.12
      Conserved Domains (1) summary
      TIGR00607
      Location:39200
      rad52; recombination protein rad52

    RNA

    1. NR_149727.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1.This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC117667
      Related
      ENSMUST00000161045.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      119878781..119899789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505767.5XP_006505830.1  DNA repair protein RAD52 homolog isoform X6

      Conserved Domains (1) summary
      TIGR00607
      Location:39200
      rad52; recombination protein rad52
    2. XM_036165958.1XP_036021851.1  DNA repair protein RAD52 homolog isoform X3

      Conserved Domains (1) summary
      TIGR00607
      Location:39200
      rad52; recombination protein rad52
    3. XM_006505764.5XP_006505827.1  DNA repair protein RAD52 homolog isoform X1

      See identical proteins and their annotated locations for XP_006505827.1

      UniProtKB/TrEMBL
      Q8VEE2
      Conserved Domains (1) summary
      TIGR00607
      Location:39200
      rad52; recombination protein rad52
    4. XM_006505765.5XP_006505828.1  DNA repair protein RAD52 homolog isoform X4

      Conserved Domains (1) summary
      cl01936
      Location:1144
      Rad52_Rad22; Rad52/22 family double-strand break repair protein
    5. XM_011241256.4XP_011239558.1  DNA repair protein RAD52 homolog isoform X2

      Conserved Domains (1) summary
      TIGR00607
      Location:39200
      rad52; recombination protein rad52
    6. XM_006505766.5XP_006505829.1  DNA repair protein RAD52 homolog isoform X5

      Conserved Domains (1) summary
      cl01936
      Location:39117
      Rad52_Rad22; Rad52/22 family double-strand break repair protein
    7. XM_036165959.1XP_036021852.1  DNA repair protein RAD52 homolog isoform X4

      Conserved Domains (1) summary
      cl01936
      Location:1144
      Rad52_Rad22; Rad52/22 family double-strand break repair protein

    RNA

    1. XR_001785110.2 RNA Sequence

    2. XR_001785111.2 RNA Sequence

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