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    Rad50 RAD50 double strand break repair protein [ Mus musculus (house mouse) ]

    Gene ID: 19360, updated on 16-Aug-2021

    Summary

    Official Symbol
    Rad50provided by MGI
    Official Full Name
    RAD50 double strand break repair proteinprovided by MGI
    Primary source
    MGI:MGI:109292
    See related
    Ensembl:ENSMUSG00000020380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mr; Rad; Mrell; Rad50l
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.4), CNS E11.5 (RPKM 4.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rad50 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.98 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53540346..53598146, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53649519..53707319, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (53463021..53520821, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene origin of replication in Il13 Neighboring gene interleukin 13 Neighboring gene ribosomal protein S2, pseudogene 4 Neighboring gene Th2 cytokine locus control region Neighboring gene interleukin 5 Neighboring gene microRNA 7671

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-quadruplex DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to single-stranded DNA endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleic acid phosphodiester bond hydrolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in telomere maintenance via recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomeric 3' overhang formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Mre11 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Mre11 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA repair protein RAD50
    Names
    RAD50 homolog
    mRad50

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009012.2NP_033038.2  DNA repair protein RAD50

      See identical proteins and their annotated locations for NP_033038.2

      Status: VALIDATED

      Source sequence(s)
      AL645741
      Consensus CDS
      CCDS24684.1
      UniProtKB/TrEMBL
      Q5SV02
      Related
      ENSMUSP00000020649.8, ENSMUST00000020649.14
      Conserved Domains (4) summary
      TIGR00606
      Location:21312
      rad50; rad50
      cd03240
      Location:11951297
      ABC_Rad50; ATP-binding cassette domain of Rad50
      pfam04423
      Location:659709
      Rad50_zn_hook; Rad50 zinc hook motif
      cl19219
      Location:8931002
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      53540346..53598146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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