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    Rad50 RAD50 double strand break repair protein [ Mus musculus (house mouse) ]

    Gene ID: 19360, updated on 18-Sep-2018

    Summary

    Official Symbol
    Rad50provided by MGI
    Official Full Name
    RAD50 double strand break repair proteinprovided by MGI
    Primary source
    MGI:MGI:109292
    See related
    Ensembl:ENSMUSG00000020380 Vega:OTTMUSG00000005644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrell; Rad50l
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.4), CNS E11.5 (RPKM 4.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rad50 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.98 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (53649519..53707319, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (53463021..53520821, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene interleukin 13 Neighboring gene ribosomal protein S2, pseudogene 4 Neighboring gene interleukin 5 Neighboring gene microRNA 7671

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to 3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ATP-dependent DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to ATP-dependent DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-quadruplex DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding, bridging ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to single-stranded DNA endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA recombination ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome organization involved in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance via recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    telomeric 3' overhang formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Mre11 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Mre11 complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA repair protein RAD50
    Names
    RAD50 homolog
    mRad50

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009012.2NP_033038.2  DNA repair protein RAD50

      See identical proteins and their annotated locations for NP_033038.2

      Status: VALIDATED

      Source sequence(s)
      AL645741
      Consensus CDS
      CCDS24684.1
      UniProtKB/TrEMBL
      Q5SV02
      Related
      ENSMUSP00000020649.7, OTTMUSP00000005819, ENSMUST00000020649.13, OTTMUST00000012555
      Conserved Domains (4) summary
      TIGR00606
      Location:21312
      rad50; rad50
      cd03240
      Location:11951297
      ABC_Rad50; ATP-binding cassette domain of Rad50
      pfam04423
      Location:659709
      Rad50_zn_hook; Rad50 zinc hook motif
      cl19219
      Location:8931002
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      53649519..53707319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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