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    Rad21 RAD21 cohesin complex component [ Mus musculus (house mouse) ]

    Gene ID: 19357, updated on 5-Sep-2021

    Summary

    Official Symbol
    Rad21provided by MGI
    Official Full Name
    RAD21 cohesin complex componentprovided by MGI
    Primary source
    MGI:MGI:108016
    See related
    Ensembl:ENSMUSG00000022314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCC; SCC1; mHR21; mKIAA0078
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 53.2), liver E14 (RPKM 45.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rad21 in Genome Data Viewer
    Location:
    15; 15 C
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (51826000..51856934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (51962604..51993538, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (51794150..51823306, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene UTP23 small subunit processome component Neighboring gene predicted gene, 34678 Neighboring gene predicted gene, 48923 Neighboring gene predicted gene, 52217 Neighboring gene protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene Neighboring gene alanine and arginine rich domain containing protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150311, MGC150312

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication-born double-strand break repair via sister chromatid exchange IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptonemal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cohesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cohesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear meiotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of nuclear mitotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    double-strand-break repair protein rad21 homolog
    Names
    PW29
    RAD21 homolog
    SCC1 homolog
    pokeweed agglutinin-binding protein 29

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009009.4NP_033035.3  double-strand-break repair protein rad21 homolog

      See identical proteins and their annotated locations for NP_033035.3

      Status: VALIDATED

      Source sequence(s)
      AK163992, AK168718, BC043032, CJ072039
      Consensus CDS
      CCDS27463.1
      UniProtKB/Swiss-Prot
      Q61550
      UniProtKB/TrEMBL
      Q3TG35
      Related
      ENSMUSP00000022927.10, ENSMUST00000022927.11
      Conserved Domains (2) summary
      pfam04824
      Location:578632
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1104
      Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      51826000..51856934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520644.1XP_006520707.1  double-strand-break repair protein rad21 homolog isoform X1

      See identical proteins and their annotated locations for XP_006520707.1

      UniProtKB/Swiss-Prot
      Q61550
      Conserved Domains (2) summary
      pfam04824
      Location:578632
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1104
      Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
    2. XM_006520645.2XP_006520708.1  double-strand-break repair protein rad21 homolog isoform X1

      See identical proteins and their annotated locations for XP_006520708.1

      UniProtKB/Swiss-Prot
      Q61550
      Conserved Domains (2) summary
      pfam04824
      Location:578632
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1104
      Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
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