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    Rab7 RAB7, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19349, updated on 24-Apr-2022

    Summary

    Official Symbol
    Rab7provided by MGI
    Official Full Name
    RAB7, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:105068
    See related
    Ensembl:ENSMUSG00000079477 AllianceGenome:MGI:105068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab7a
    Summary
    Predicted to enable several functions, including guanyl ribonucleotide binding activity; retromer complex binding activity; and small GTPase binding activity. Involved in lipophagy. Acts upstream of or within with a positive effect on establishment of vesicle localization. Located in several cellular components, including late endosome membrane; lipid droplet; and phagophore assembly site membrane. Is extrinsic component of lysosome membrane. Is active in lysosome. Is expressed in limb mesenchyme and lung mesenchyme. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 76.7), kidney adult (RPKM 66.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab7 in Genome Data Viewer
    Location:
    6 D1; 6 39.13 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87976088..88022252, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87999106..88045270, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (87950429..87963684, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5577 Neighboring gene H1.10 linker histone Neighboring gene predicted gene, 34872 Neighboring gene predicted gene, 38855 Neighboring gene ribophorin I Neighboring gene microRNA 6376

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102153

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retromer complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect establishment of vesicle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intracellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagosome acidification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagosome-lysosome fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phagosome-lysosome fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein to membrane docking ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in alveolar lamellar body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in anchored component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of lysosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-7a
    NP_001280581.1
    NP_001280582.1
    NP_001280583.1
    NP_001280584.1
    NP_033031.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293652.1NP_001280581.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001280581.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK152666, AK158971, BY291181, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000109226.2, ENSMUST00000113596.8
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)
    2. NM_001293653.1NP_001280582.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001280582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK158971, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000109228.2, ENSMUST00000113598.8
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)
    3. NM_001293654.1NP_001280583.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001280583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK135659, AK158971, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000109227.2, ENSMUST00000113597.8
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)
    4. NM_001293655.1NP_001280584.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001280584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK135659, AK139914, AK158971, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000092658.4, ENSMUST00000095048.6
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)
    5. NM_009005.3NP_033031.2  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_033031.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK148117, AK158971, BY291181, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000109230.4, ENSMUST00000113600.10
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      87976088..88022252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)