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    Rab7 RAB7, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19349, updated on 9-Sep-2018

    Summary

    Official Symbol
    Rab7provided by MGI
    Official Full Name
    RAB7, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:105068
    See related
    Ensembl:ENSMUSG00000079477 Vega:OTTMUSG00000024646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab7a
    Expression
    Ubiquitous expression in bladder adult (RPKM 76.7), kidney adult (RPKM 66.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rab7 in Genome Data Viewer
    Location:
    6 D1; 6 39.13 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (87999106..88045270, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (87950429..87963684, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5577 Neighboring gene H1 histone family, member X Neighboring gene predicted gene, 34872 Neighboring gene predicted gene, 38855 Neighboring gene ribophorin I Neighboring gene microRNA 6376

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Mitophagy - animal, organism-specific biosystem (from KEGG)
      Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Mitophagy - animal, conserved biosystem (from KEGG)
      Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
      RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
      TBC/RABGAPs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102153

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Rac GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retromer complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    phagosome acidification ISO
    Inferred from Sequence Orthology
    more info
     
    phagosome-lysosome fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagosome-lysosome fusion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    protein to membrane docking ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alveolar lamellar body ISO
    Inferred from Sequence Orthology
    more info
     
    anchored component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of lysosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with retromer complex ISO
    Inferred from Sequence Orthology
    more info
     
    vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293652.1NP_001280581.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001280581.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK152666, AK158971, BY291181, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000109226.1, OTTMUSP00000029565, ENSMUST00000113596.7, OTTMUST00000060593
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)
    2. NM_001293653.1NP_001280582.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001280582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK158971, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000109228.1, OTTMUSP00000029562, ENSMUST00000113598.7, OTTMUST00000060590
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)
    3. NM_001293654.1NP_001280583.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001280583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK135659, AK158971, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000109227.1, OTTMUSP00000029564, ENSMUST00000113597.7, OTTMUST00000060592
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)
    4. NM_001293655.1NP_001280584.1  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_001280584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK135659, AK139914, AK158971, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000092658.3, OTTMUSP00000029563, ENSMUST00000095048.5, OTTMUST00000060591
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)
    5. NM_009005.3NP_033031.2  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_033031.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK148117, AK158971, BY291181, CD774636
      Consensus CDS
      CCDS39552.1
      UniProtKB/Swiss-Prot
      P51150
      UniProtKB/TrEMBL
      Q4FJQ0
      Related
      ENSMUSP00000109230.3, OTTMUSP00000029561, ENSMUST00000113600.9, OTTMUST00000060589
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      87999106..88045270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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