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    Dennd5a DENN/MADD domain containing 5A [ Mus musculus (house mouse) ]

    Gene ID: 19347, updated on 19-Mar-2019

    Summary

    Official Symbol
    Dennd5aprovided by MGI
    Official Full Name
    DENN/MADD domain containing 5Aprovided by MGI
    Primary source
    MGI:MGI:1201681
    See related
    Ensembl:ENSMUSG00000035901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF37; Rab6ip1; AJ245569; AW496491; mKIAA1091; 1500012B19Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 51.7), frontal lobe adult (RPKM 39.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dennd5a in Genome Data Viewer
    Location:
    7; 7 E3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (109893780..109960470, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (117037294..117103936, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene nuclear receptor interacting protein 3 Neighboring gene signal peptide, CUB domain, EGF-like 2 Neighboring gene transmembrane protein 41B Neighboring gene RIKEN cDNA 1600010M07 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rab GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rab guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with retromer complex ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DENN domain-containing protein 5A
    Names
    Rab6 interacting protein 1
    rab6-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311139.1NP_001298068.1  DENN domain-containing protein 5A isoform 2

      See identical proteins and their annotated locations for NP_001298068.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC140235, BC060230
      Consensus CDS
      CCDS80781.1
      UniProtKB/Swiss-Prot
      Q6PAL8
      UniProtKB/TrEMBL
      A0A0R4J1B6
      Related
      ENSMUSP00000102333.1, ENSMUST00000106722.1
      Conserved Domains (6) summary
      smart00801
      Location:489564
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00593
      Location:860923
      RUN; domain involved in Ras-like GTPase signaling
      smart00800
      Location:12114
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01757
      Location:9301038
      PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
      pfam02141
      Location:178366
      DENN; DENN (AEX-3) domain
      cl02689
      Location:11191257
      RUN; RUN domain
    2. NM_021494.1NP_067469.1  DENN domain-containing protein 5A isoform 1

      See identical proteins and their annotated locations for NP_067469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC060230
      Consensus CDS
      CCDS21741.1
      UniProtKB/Swiss-Prot
      Q6PAL8
      Related
      ENSMUSP00000079295.6, ENSMUST00000080437.12
      Conserved Domains (6) summary
      smart00801
      Location:513588
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00593
      Location:884947
      RUN; domain involved in Ras-like GTPase signaling
      smart00800
      Location:12138
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01757
      Location:9541062
      PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
      pfam02141
      Location:202390
      DENN; DENN (AEX-3) domain
      cl02689
      Location:11431281
      RUN; RUN domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      109893780..109960470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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