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    Rab6a RAB6A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19346, updated on 22-Aug-2021

    Summary

    Official Symbol
    Rab6aprovided by MGI
    Official Full Name
    RAB6A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:894313
    See related
    Ensembl:ENSMUSG00000030704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ra; Rab6; AA419671; 2610028L11Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 77.2), CNS E18 (RPKM 68.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab6a in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100256778..100290475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100607575..100641268)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (107756100..107789782)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39059 Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene cytochrome c oxidase assembly protein 20B Neighboring gene pleckstrin homology domain containing, family B (evectins) member 1 Neighboring gene predicted gene, 53385 Neighboring gene predicted gene, 35082

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome to plasma membrane transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-6A
    Names
    RAB6, member RAS oncogene family
    rab-6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163663.1NP_001157135.1  ras-related protein Rab-6A isoform 1

      See identical proteins and their annotated locations for NP_001157135.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (1) encodes isoform 1.
      Source sequence(s)
      AC124531, AK084131, BE134038, BP765476, CX734203
      Consensus CDS
      CCDS52323.1
      UniProtKB/Swiss-Prot
      P35279
      UniProtKB/TrEMBL
      Q3U4W5
      Related
      ENSMUSP00000095852.5, ENSMUST00000098252.5
      Conserved Domains (1) summary
      cd01861
      Location:14174
      Rab6; Rab GTPase family 6 (Rab6)
    2. NM_024287.4NP_077249.1  ras-related protein Rab-6A isoform 2

      See identical proteins and their annotated locations for NP_077249.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (2) encodes isoform 2.
      Source sequence(s)
      AC124531, AK084131, BP765476, CX734203
      Consensus CDS
      CCDS21503.1
      UniProtKB/Swiss-Prot
      P35279
      UniProtKB/TrEMBL
      Q0PD54
      Related
      ENSMUSP00000032946.4, ENSMUST00000032946.10
      Conserved Domains (1) summary
      cd01861
      Location:14174
      Rab6; Rab GTPase family 6 (Rab6)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100256778..100290475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003946421.2 RNA Sequence

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