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    Rab6a RAB6A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19346, updated on 18-Sep-2024

    Summary

    Official Symbol
    Rab6aprovided by MGI
    Official Full Name
    RAB6A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:894313
    See related
    Ensembl:ENSMUSG00000030704 AllianceGenome:MGI:894313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab6; 2610028L11Rik
    Summary
    Predicted to enable several functions, including ATPase binding activity; GTP binding activity; and myosin V binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; intracellular protein transport; and protein localization to Golgi apparatus. Predicted to act upstream of or within peptidyl-cysteine methylation. Located in Golgi apparatus. Is expressed in several structures, including diaphragm; nervous system; sensory organ; and tooth. Orthologous to human RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 77.2), CNS E18 (RPKM 68.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rab6a in Genome Data Viewer
    Location:
    7 E2; 7 54.36 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100256778..100290475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100607575..100641268)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39059 Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene STARR-positive B cell enhancer ABC_E9294 Neighboring gene STARR-positive B cell enhancer ABC_E6573 Neighboring gene cytochrome c oxidase assembly protein 20B Neighboring gene STARR-positive B cell enhancer ABC_E1738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107756073-107756182 Neighboring gene pleckstrin homology domain containing, family B (evectins) member 1 Neighboring gene predicted gene, 53385 Neighboring gene predicted gene, 35082

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables myosin V binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in early endosome to Golgi transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptidyl-cysteine methylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within peptidyl-cysteine methylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome to plasma membrane transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome to plasma membrane transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-6A
    Names
    RAB6, member RAS oncogene family
    rab-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163663.2NP_001157135.1  ras-related protein Rab-6A isoform 1

      See identical proteins and their annotated locations for NP_001157135.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (1) encodes isoform 1.
      Source sequence(s)
      AC124531
      Consensus CDS
      CCDS52323.1
      UniProtKB/TrEMBL
      D3YV69, Q3U4W5
      Related
      ENSMUSP00000095852.5, ENSMUST00000098252.5
      Conserved Domains (1) summary
      cd01861
      Location:14174
      Rab6; Rab GTPase family 6 (Rab6)
    2. NM_024287.5NP_077249.1  ras-related protein Rab-6A isoform 2

      See identical proteins and their annotated locations for NP_077249.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (2) encodes isoform 2.
      Source sequence(s)
      AC124531
      Consensus CDS
      CCDS21503.1
      UniProtKB/Swiss-Prot
      P35279, Q542M6, Q8R2Z7, Q8VEE5, Q9JJD4
      UniProtKB/TrEMBL
      D3YV69, Q0PD54
      Related
      ENSMUSP00000032946.4, ENSMUST00000032946.10
      Conserved Domains (1) summary
      cd01861
      Location:14174
      Rab6; Rab GTPase family 6 (Rab6)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100256778..100290475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003946421.2 RNA Sequence