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    Rab3a RAB3A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19339, updated on 5-Sep-2021

    Summary

    Official Symbol
    Rab3aprovided by MGI
    Official Full Name
    RAB3A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:97843
    See related
    Ensembl:ENSMUSG00000031840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in cerebellum adult (RPKM 223.6), cortex adult (RPKM 207.3) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Rab3a in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71207258..71211276)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70754703..70758608)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (73278578..73282585)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34255 Neighboring gene predicted gene 3336 Neighboring gene phosphodiesterase 4C, cAMP specific Neighboring gene RIKEN cDNA 6330537M06 gene Neighboring gene MPV17 mitochondrial membrane protein-like 2 Neighboring gene interferon gamma inducible protein 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP-dissociation inhibitor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acrosomal vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-ion regulated exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in evoked neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of presynaptic active zone structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within maintenance of presynaptic active zone structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of regulated secretory pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of long-term synaptic potentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of short-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to electrical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptic vesicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in anchored component of synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in anchored component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-sculpted glutamate transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166399.3NP_001159871.1  ras-related protein Rab-3A

      See identical proteins and their annotated locations for NP_001159871.1

      Status: VALIDATED

      Source sequence(s)
      CAAA01070179
      Consensus CDS
      CCDS22379.1
      UniProtKB/Swiss-Prot
      P63011
      UniProtKB/TrEMBL
      Q0PD63
      Related
      ENSMUSP00000105720.3, ENSMUST00000110093.9
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    2. NM_001328047.2NP_001314976.1  ras-related protein Rab-3A

      Status: VALIDATED

      Source sequence(s)
      CAAA01070179
      Consensus CDS
      CCDS22379.1
      UniProtKB/Swiss-Prot
      P63011
      UniProtKB/TrEMBL
      Q0PD63
      Related
      ENSMUSP00000105717.2, ENSMUST00000110090.8
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    3. NM_001378892.1NP_001365821.1  ras-related protein Rab-3A

      Status: VALIDATED

      Source sequence(s)
      CAAA01070179
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    4. NM_001378893.1NP_001365822.1  ras-related protein Rab-3A

      Status: VALIDATED

      Source sequence(s)
      CAAA01070179
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    5. NM_009001.7NP_033027.1  ras-related protein Rab-3A

      See identical proteins and their annotated locations for NP_033027.1

      Status: VALIDATED

      Source sequence(s)
      CAAA01070179
      Consensus CDS
      CCDS22379.1
      UniProtKB/Swiss-Prot
      P63011
      UniProtKB/TrEMBL
      Q0PD63
      Related
      ENSMUSP00000034301.6, ENSMUST00000034301.12
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71207258..71211276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153836.1XP_036009729.1  ras-related protein Rab-3A isoform X1

      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
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