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    Rab3a RAB3A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19339, updated on 23-Oct-2018

    Summary

    Official Symbol
    Rab3aprovided by MGI
    Official Full Name
    RAB3A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:97843
    See related
    Ensembl:ENSMUSG00000031840 Vega:OTTMUSG00000016949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in cerebellum adult (RPKM 223.6), cortex adult (RPKM 207.3) and 13 other tissues See more
    Orthologs

    Genomic context

    See Rab3a in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (70754679..70758686)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (73278578..73282585)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34255 Neighboring gene predicted gene 3336 Neighboring gene phosphodiesterase 4C, cAMP specific Neighboring gene MPV17 mitochondrial membrane protein-like 2 Neighboring gene interferon gamma inducible protein 30 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    GDP-dissociation inhibitor binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    evoked neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of presynaptic active zone structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    maintenance of presynaptic active zone structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of regulated secretory pathway ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of long-term synaptic potentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of short-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to electrical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle recycling ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle transport TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anchored component of synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anchored component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anchored component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166399.2NP_001159871.1  ras-related protein Rab-3A

      See identical proteins and their annotated locations for NP_001159871.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1,2 and 3 encode the same protein.
      Source sequence(s)
      AK005362, BU843202, BY097011
      Consensus CDS
      CCDS22379.1
      UniProtKB/Swiss-Prot
      P63011
      UniProtKB/TrEMBL
      Q0PD63
      Related
      ENSMUSP00000105720.2, OTTMUSP00000025402, ENSMUST00000110093.8, OTTMUST00000053431
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    2. NM_001328047.1NP_001314976.1  ras-related protein Rab-3A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1,2 and 3 encode the same protein.
      Source sequence(s)
      AK161975, BU843202, BY097011, CX238545
      Consensus CDS
      CCDS22379.1
      UniProtKB/Swiss-Prot
      P63011
      UniProtKB/TrEMBL
      Q0PD63
      Related
      ENSMUSP00000105717.1, OTTMUSP00000018420, ENSMUST00000110090.7, OTTMUST00000041120
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
    3. NM_009001.6NP_033027.1  ras-related protein Rab-3A

      See identical proteins and their annotated locations for NP_033027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splicing site in the 5' UTR, and is a shorter transcript, as compared to variant 1. Variants 1,2 and 3 encode the same protein.
      Source sequence(s)
      AK161975, BU843202, BY097011
      Consensus CDS
      CCDS22379.1
      UniProtKB/Swiss-Prot
      P63011
      UniProtKB/TrEMBL
      Q0PD63
      Related
      ENSMUSP00000034301.5, OTTMUSP00000018415, ENSMUST00000034301.11, OTTMUST00000041105
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      70754679..70758686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509603.3XP_006509666.1  ras-related protein Rab-3A isoform X1

      See identical proteins and their annotated locations for XP_006509666.1

      UniProtKB/Swiss-Prot
      P63011
      UniProtKB/TrEMBL
      Q0PD63
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
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