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    Rab23 RAB23, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19335, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rab23provided by MGI
    Official Full Name
    RAB23, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:99833
    See related
    Ensembl:ENSMUSG00000004768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    opb; opb2; AW545388
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.6), limb E14.5 (RPKM 5.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab23 in Genome Data Viewer
    Location:
    1 B; 1 12.8 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33758959..33781645)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33719896..33742564)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (33776741..33799409)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001G17 gene Neighboring gene predicted gene, 32229 Neighboring gene BCL2-associated athanogene 2 Neighboring gene zinc finger protein 451

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular defense response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in craniofacial suture morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dorsal/ventral neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-23
    Names
    open brain 2
    protein open brain
    rab-15
    NP_001153201.1
    NP_033025.2
    XP_006495864.1
    XP_006495865.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159729.1NP_001153201.1  ras-related protein Rab-23

      See identical proteins and their annotated locations for NP_001153201.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AC163668, AK016493
      Consensus CDS
      CCDS35532.1
      UniProtKB/TrEMBL
      Q9D4I9
      Related
      ENSMUSP00000110828.2, ENSMUST00000115174.4
      Conserved Domains (1) summary
      cd04106
      Location:10169
      Rab23_like; Rab GTPase family 23 (Rab23)-like
    2. NM_008999.4NP_033025.2  ras-related protein Rab-23

      See identical proteins and their annotated locations for NP_033025.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AC163668, AK047068
      Consensus CDS
      CCDS35532.1
      UniProtKB/TrEMBL
      Q9D4I9
      Related
      ENSMUSP00000085625.4, ENSMUST00000088287.10
      Conserved Domains (1) summary
      cd04106
      Location:10169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      33758959..33781645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495802.5XP_006495865.1  ras-related protein Rab-23 isoform X1

      See identical proteins and their annotated locations for XP_006495865.1

      UniProtKB/TrEMBL
      Q9D4I9
      Conserved Domains (1) summary
      cd04106
      Location:10169
      Rab23_like; Rab GTPase family 23 (Rab23)-like
    2. XM_006495801.5XP_006495864.1  ras-related protein Rab-23 isoform X1

      See identical proteins and their annotated locations for XP_006495864.1

      UniProtKB/TrEMBL
      Q9D4I9
      Conserved Domains (1) summary
      cd04106
      Location:10169
      Rab23_like; Rab GTPase family 23 (Rab23)-like
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