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    Rab23 RAB23, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19335, updated on 12-Aug-2018

    Summary

    Official Symbol
    Rab23provided by MGI
    Official Full Name
    RAB23, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:99833
    See related
    Ensembl:ENSMUSG00000004768 Vega:OTTMUSG00000021871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    opb; opb2; AW545388
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.6), limb E14.5 (RPKM 5.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rab23 in Genome Data Viewer
    Location:
    1 B; 1 12.8 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (33719888..33742564)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (33776741..33799409)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene DNA primase, p58 subunit Neighboring gene RIKEN cDNA 1700001G17 gene Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene predicted gene, 32229 Neighboring gene BCL2-associated athanogene 2 Neighboring gene zinc finger protein 451

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cellular defense response ISO
    Inferred from Sequence Orthology
    more info
     
    cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    craniofacial suture morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    dorsal/ventral neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spinal cord dorsal/ventral patterning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spinal cord dorsal/ventral patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-23
    Names
    open brain 2
    protein open brain
    rab-15

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159729.1NP_001153201.1  ras-related protein Rab-23

      See identical proteins and their annotated locations for NP_001153201.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AC163668, AK016493
      Consensus CDS
      CCDS35532.1
      UniProtKB/TrEMBL
      Q9D4I9
      Related
      ENSMUSP00000110828.1, OTTMUSP00000024510, ENSMUST00000115174.3, OTTMUST00000051909
      Conserved Domains (2) summary
      cd04106
      Location:10169
      Rab23_like; Rab GTPase family 23 (Rab23)-like
      pfam00071
      Location:11168
      Ras; Ras family
    2. NM_008999.4NP_033025.2  ras-related protein Rab-23

      See identical proteins and their annotated locations for NP_033025.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AC163668, AK047068
      Consensus CDS
      CCDS35532.1
      UniProtKB/TrEMBL
      Q9D4I9
      Related
      ENSMUSP00000085625.3, OTTMUSP00000024509, ENSMUST00000088287.9, OTTMUST00000051907
      Conserved Domains (2) summary
      cd04106
      Location:10169
      Rab23_like; Rab GTPase family 23 (Rab23)-like
      pfam00071
      Location:11168
      Ras; Ras family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      33719888..33742564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495801.3XP_006495864.1  ras-related protein Rab-23 isoform X1

      See identical proteins and their annotated locations for XP_006495864.1

      UniProtKB/TrEMBL
      Q9D4I9
      Conserved Domains (2) summary
      cd04106
      Location:10169
      Rab23_like; Rab GTPase family 23 (Rab23)-like
      pfam00071
      Location:11168
      Ras; Ras family
    2. XM_006495802.3XP_006495865.1  ras-related protein Rab-23 isoform X1

      See identical proteins and their annotated locations for XP_006495865.1

      UniProtKB/TrEMBL
      Q9D4I9
      Conserved Domains (2) summary
      cd04106
      Location:10169
      Rab23_like; Rab GTPase family 23 (Rab23)-like
      pfam00071
      Location:11168
      Ras; Ras family
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