Format

Send to:

Choose Destination
    • Showing Current items.

    Rab18 RAB18, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19330, updated on 24-Feb-2019

    Summary

    Official Symbol
    Rab18provided by MGI
    Official Full Name
    RAB18, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:102790
    See related
    Ensembl:ENSMUSG00000073639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA959686
    Summary
    This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein is expressed predominantly in lipid droplets, organelles that store neutral lipids, and is proposed to play a role in lipolysis and lipogenesis. In humans mutations in this gene are associated with Warburg micro syndrome type 3. A pseudogene of this gene is located on chromosome X. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in bladder adult (RPKM 20.0), CNS E18 (RPKM 19.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See Rab18 in Genome Data Viewer
    Location:
    18 A1; 18 4.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (6765167..6791606)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (6765203..6790229)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921524L21 gene Neighboring gene phosphoglycerate kinase 1 pseudogene Neighboring gene mohawk homeobox Neighboring gene predicted gene, 46633 Neighboring gene predicted gene 10350

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Chemically induced (ENU) (1)  1 citation

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
     
    import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid droplet organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-18
    Names
    GTP-binding protein Rab18

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278447.1NP_001265376.1  ras-related protein Rab-18 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131796
      Related
      ENSMUSP00000157198.1, ENSMUST00000234626.1
      Conserved Domains (1) summary
      cd01863
      Location:9175
      Rab18; Rab GTPase family 18 (Rab18)
    2. NM_181070.6NP_851415.1  ras-related protein Rab-18 isoform 2 precursor

      See identical proteins and their annotated locations for NP_851415.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC131796, AK034242, BC056351
      Consensus CDS
      CCDS29044.1
      UniProtKB/Swiss-Prot
      P35293
      UniProtKB/TrEMBL
      Q0PD38
      Related
      ENSMUSP00000157011.1, ENSMUST00000234810.1
      Conserved Domains (1) summary
      cd01863
      Location:9169
      Rab18; Rab GTPase family 18 (Rab18)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      6765167..6791606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center