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    Qk quaking, KH domain containing RNA binding [ Mus musculus (house mouse) ]

    Gene ID: 19317, updated on 6-Sep-2021

    Summary

    Official Symbol
    Qkprovided by MGI
    Official Full Name
    quaking, KH domain containing RNA bindingprovided by MGI
    Primary source
    MGI:MGI:97837
    See related
    Ensembl:ENSMUSG00000062078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    QkI; l17W; l(17)-1; l17Wis1; 1500005P18; l(17)-1Wis; 1110003F05Rik
    Expression
    Broad expression in frontal lobe adult (RPKM 30.8), cerebellum adult (RPKM 26.6) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    17 A1; 17 7.75 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (10425400..10538706, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (10206471..10319361, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (10399336..10512226, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34799 Neighboring gene predicted gene, 34972 Neighboring gene RIKEN cDNA 1700110C19 gene Neighboring gene predicted gene, 46608 Neighboring gene colon adenocarcinoma hypermethylated RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within 3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatid development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein quaking
    Names
    QKI-5 protein
    QKI-6 protein
    QKI-7 protein
    QKI-7b protein
    lethal, Chr 17, U Wisconsin 1
    quaking

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159516.1NP_001152988.1  protein quaking isoform 2

      See identical proteins and their annotated locations for NP_001152988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC113114, AK132303
      Consensus CDS
      CCDS88989.1
      UniProtKB/Swiss-Prot
      Q9QYS9
      Related
      ENSMUSP00000156665.2, ENSMUST00000233828.2
      Conserved Domains (3) summary
      PRK14951
      Location:210281
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      pfam16544
      Location:1066
      STAR_dimer; Homodimerization region of STAR domain protein
      cd22465
      Location:81183
      KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
    2. NM_001159517.1NP_001152989.1  protein quaking isoform 1

      See identical proteins and their annotated locations for NP_001152989.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK132303, BB674938, BC056346
      Consensus CDS
      CCDS49947.1
      UniProtKB/Swiss-Prot
      Q9QYS9
      Related
      ENSMUSP00000156511.2, ENSMUST00000233645.2
      Conserved Domains (4) summary
      PHA03247
      Location:211314
      PHA03247; large tegument protein UL36; Provisional
      pfam16544
      Location:1066
      STAR_dimer; Homodimerization region of STAR domain protein
      pfam16551
      Location:312341
      Quaking_NLS; Putative nuclear localization signal of quaking
      cd22465
      Location:81183
      KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
    3. NM_021881.2NP_068681.1  protein quaking isoform 3

      See identical proteins and their annotated locations for NP_068681.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC113114, AK132303
      Consensus CDS
      CCDS28387.1
      UniProtKB/Swiss-Prot
      Q9QYS9
      Related
      ENSMUSP00000046740.8, ENSMUST00000042296.9
      Conserved Domains (3) summary
      PRK14951
      Location:210281
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      pfam16544
      Location:1066
      STAR_dimer; Homodimerization region of STAR domain protein
      cd22465
      Location:81183
      KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      10425400..10538706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523300.4XP_006523363.1  protein quaking isoform X1

      See identical proteins and their annotated locations for XP_006523363.1

      Conserved Domains (4) summary
      PRK14950
      Location:195305
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam16544
      Location:1066
      STAR_dimer; Homodimerization region of STAR domain protein
      pfam16551
      Location:304333
      Quaking_NLS; Putative nuclear localization signal of quaking
      cd22465
      Location:81183
      KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
    2. XM_030249598.2XP_030105458.1  protein quaking isoform X2

      Conserved Domains (3) summary
      PRK14971
      Location:182311
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam16544
      Location:1066
      STAR_dimer; Homodimerization region of STAR domain protein
      cl00098
      Location:81183
      KH-I; K homology (KH) RNA-binding domain, type I

    RNA

    1. XR_385167.4 RNA Sequence

    2. XR_385168.4 RNA Sequence

    3. XR_385170.4 RNA Sequence

    4. XR_385169.4 RNA Sequence

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