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    Pex5 peroxisomal biogenesis factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 19305, updated on 31-Jan-2019

    Summary

    Official Symbol
    Pex5provided by MGI
    Official Full Name
    peroxisomal biogenesis factor 5provided by MGI
    Primary source
    MGI:MGI:1098808
    See related
    Ensembl:ENSMUSG00000005069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pxr1; ESTM1; PTS1R; PXR1P; X83306; PTS1-BP; AW212715
    Expression
    Ubiquitous expression in liver adult (RPKM 17.6), subcutaneous fat pad adult (RPKM 13.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pex5 in Genome Data Viewer
    Location:
    6 F2; 6 59.15 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (124396816..124418181, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (124346834..124365085, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700013D24 gene Neighboring gene RIKEN cDNA 1700027F06 gene Neighboring gene RIKEN cDNA D830015G05 gene Neighboring gene calsyntenin 3 Neighboring gene complement component 1, r subcomponent-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Peroxisome, organism-specific biosystem (from KEGG)
      Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Peroxisome, conserved biosystem (from KEGG)
      Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome matrix targeting signal-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisome matrix targeting signal-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome matrix targeting signal-1 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peroxisome targeting sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome targeting sequence binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT isoprenoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peroxisome organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into peroxisome matrix ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into peroxisome matrix, docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein import into peroxisome matrix, docking ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into peroxisome matrix, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into peroxisome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein targeting to peroxisome TAS
    Traceable Author Statement
    more info
    PubMed 
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    very long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxisomal targeting signal 1 receptor; peroxisomal biogenesis factor 5
    Names
    PTS1 receptor
    peroxin 5
    peroxisomal C-terminal targeting signal import receptor
    peroxisome biogenesis factor 5
    peroxisome receptor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277330.1NP_001264259.1  peroxisomal targeting signal 1 receptor isoform 2

      See identical proteins and their annotated locations for NP_001264259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 2 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC124470, AK161470, BY442904
      Consensus CDS
      CCDS20518.1
      UniProtKB/Swiss-Prot
      O09012
      Related
      ENSMUSP00000108150.1, ENSMUST00000112531.7
      Conserved Domains (2) summary
      sd00006
      Location:451479
      TPR; TPR repeat [structural motif]
      cl26002
      Location:311546
      TPR_11; TPR repeat
    2. NM_001277805.1NP_001264734.1  peroxisomal targeting signal 1 receptor isoform 1

      See identical proteins and their annotated locations for NP_001264734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR compared to variant 1. Variant 1 and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AC124470
      Consensus CDS
      CCDS20517.1
      UniProtKB/Swiss-Prot
      O09012
      Related
      ENSMUSP00000049132.5, ENSMUST00000035861.5
      Conserved Domains (4) summary
      COG0457
      Location:276556
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:488516
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:488521
      TPR_1; Tetratricopeptide repeat
      cl02686
      Location:307342
      PRY; SPRY-associated domain
    3. NM_001360570.1NP_001347499.1  peroxisomal targeting signal 1 receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124470
      Conserved Domains (2) summary
      sd00006
      Location:451479
      TPR; TPR repeat [structural motif]
      cl26002
      Location:311546
      TPR_11; TPR repeat
    4. NM_008995.2NP_033021.2  peroxisomal targeting signal 1 receptor isoform 1

      See identical proteins and their annotated locations for NP_033021.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Variants 1 and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AC124470
      Consensus CDS
      CCDS20517.1
      UniProtKB/Swiss-Prot
      O09012
      Related
      ENSMUSP00000108151.1, ENSMUST00000112532.7
      Conserved Domains (4) summary
      COG0457
      Location:276556
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:488516
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:488521
      TPR_1; Tetratricopeptide repeat
      cl02686
      Location:307342
      PRY; SPRY-associated domain
    5. NM_175933.2NP_787947.1  peroxisomal targeting signal 1 receptor isoform 2

      See identical proteins and their annotated locations for NP_787947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 2 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AC124470, AK161470
      Consensus CDS
      CCDS20518.1
      UniProtKB/Swiss-Prot
      O09012
      Related
      ENSMUSP00000079398.5, ENSMUST00000080557.11
      Conserved Domains (2) summary
      sd00006
      Location:451479
      TPR; TPR repeat [structural motif]
      cl26002
      Location:311546
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      124396816..124418181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321462.1XP_017176951.1  peroxisomal biogenesis factor 5 isoform X2

      UniProtKB/Swiss-Prot
      O09012
      Conserved Domains (2) summary
      sd00006
      Location:451479
      TPR; TPR repeat [structural motif]
      cl26002
      Location:311546
      TPR_11; TPR repeat
    2. XM_006505758.3XP_006505821.1  peroxisomal biogenesis factor 5 isoform X1

      See identical proteins and their annotated locations for XP_006505821.1

      UniProtKB/Swiss-Prot
      O09012
      Conserved Domains (4) summary
      COG0457
      Location:276556
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:488516
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:488521
      TPR_1; Tetratricopeptide repeat
      cl02686
      Location:307342
      PRY; SPRY-associated domain
    3. XM_006505759.3XP_006505822.1  peroxisomal biogenesis factor 5 isoform X1

      See identical proteins and their annotated locations for XP_006505822.1

      UniProtKB/Swiss-Prot
      O09012
      Conserved Domains (4) summary
      COG0457
      Location:276556
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:488516
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:488521
      TPR_1; Tetratricopeptide repeat
      cl02686
      Location:307342
      PRY; SPRY-associated domain
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