Pxn paxillin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pxnprovided by MGI
Official Full Name: paxillinprovided by MGI
Primary source: MGI:MGI:108295
See related: Ensembl:ENSMUSG00000029528 AllianceGenome:MGI:108295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pax
Summary: Enables BH4 domain binding activity; MAP-kinase scaffold activity; and neuropilin binding activity. Involved in positive regulation of angiogenesis and transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including focal adhesion assembly; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Located in focal adhesion and lamellipodium. Is expressed in several structures, including early conceptus; genitourinary system; immune system; inner ear; and telencephalon. Orthologous to human PXN (paxillin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 49.8), colon adult (RPKM 41.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.1 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_04	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115630035..115694046)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115491970..115555987)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Critical Balance Between PAX8 and the Hippo Mediator TAZ Determines Sodium/Iodide Symporter Expression and Function.
Title: A Critical Balance Between PAX8 and the Hippo Mediator TAZ Determines Sodium/Iodide Symporter Expression and Function.
Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity.
Title: Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity.
Structural and functional analysis of LIM domain-dependent recruitment of paxillin to alphavbeta3 integrin-positive focal adhesions.
Title: Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.
Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome.
Title: Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome.
Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma.
Title: Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma.
Despite sharing the same binding mode with leupaxin, paxillin recruitment into podosomes is kindlin-3 independent.
Title: A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.
the focal adhesion component paxillin is a cytoplasmic substrate of Ccnd1.Cdk4.
Title: Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.
Title: Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin.
Kindlin-2 is a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with the Arp2/3 complex.
Title: Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.
paxillin and FAK function cell-autonomously to control migrating neuron morphology and speed during cortical development.
Title: Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC133539P1 (e-PCR)
- UniSTS:270624

AW123232 (e-PCR)
- UniSTS:179243

AW108311 (e-PCR)
- UniSTS:179246

Pxn (e-PCR), detects polymorphism
- UniSTS:256487

Pxn (e-PCR), detects polymorphism
- UniSTS:256488

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BH4 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables MAP-kinase scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neuropilin binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropilin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	TAS Traceable Author Statement more info	PubMed
enables vinculin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within integrin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within lamellipodium assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to peptide	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	TAS Traceable Author Statement more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paxillin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403066.1 → NP_001389995.1 paxillin isoform 3

Status: VALIDATED

Source sequence(s)

AC159539
NM_001403067.1 → NP_001389996.1 paxillin isoform 4

Status: VALIDATED

Source sequence(s)

AC159539
NM_001403068.1 → NP_001389997.1 paxillin isoform 5

Status: VALIDATED

Source sequence(s)

AC159539

UniProtKB/TrEMBL

A0A0J9YV30
NM_001403069.1 → NP_001389998.1 paxillin isoform 5

Status: VALIDATED

Source sequence(s)

AC159539

UniProtKB/TrEMBL

A0A0J9YV30
NM_001403070.1 → NP_001389999.1 paxillin isoform 5

Status: VALIDATED

Source sequence(s)

AC159539

UniProtKB/TrEMBL

A0A0J9YV30
NM_011223.4 → NP_035353.1 paxillin isoform alpha

See identical proteins and their annotated locations for NP_035353.1

Status: VALIDATED

Source sequence(s)

AC159539

Consensus CDS

CCDS19593.1

UniProtKB/Swiss-Prot

Q8VI36

Related

ENSMUSP00000069624.9, ENSMUST00000067268.15

Conserved Domains (5) summary

cd09407
Location:383 → 434

LIM2_Paxillin; The second LIM domain of paxillin

cd09409
Location:442 → 494

LIM3_Paxillin; The third LIM domain of paxillin

cd09411
Location:501 → 552

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:324 → 376

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_133915.4 → NP_598676.2 paxillin isoform beta

See identical proteins and their annotated locations for NP_598676.2

Status: VALIDATED

Source sequence(s)

AC159539

Consensus CDS

CCDS39229.1

UniProtKB/Swiss-Prot

Q8VI36

UniProtKB/TrEMBL

F8VQ28

Related

ENSMUSP00000083709.4, ENSMUST00000086523.7

Conserved Domains (5) summary

cd09338
Location:476 → 528

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:417 → 468

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:535 → 586

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:358 → 410

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family

RNA

NR_175347.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC159539

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

115630035..115694046

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254218.2 → XP_030110078.1 paxillin isoform X7

Related

ENSMUSP00000144459.2, ENSMUST00000202564.2

Conserved Domains (5) summary

cd09338
Location:343 → 395

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09411
Location:402 → 453

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:225 → 277

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

cl02475
Location:284 → 335

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam03535
Location:1 → 120

Paxillin; Paxillin family
XM_036164917.1 → XP_036020810.1 paxillin isoform X2

Conserved Domains (5) summary

cd09338
Location:842 → 894

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:783 → 834

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:901 → 952

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:724 → 776

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
XM_036164918.1 → XP_036020811.1 paxillin isoform X4

Conserved Domains (5) summary

cd09338
Location:753 → 805

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:694 → 745

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:812 → 863

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:635 → 687

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
XM_006530207.5 → XP_006530270.1 paxillin isoform X5

Conserved Domains (1) summary

pfam03535
Location:54 → 253

Paxillin; Paxillin family
XM_006530205.4 → XP_006530268.1 paxillin isoform X3

See identical proteins and their annotated locations for XP_006530268.1

Conserved Domains (5) summary

cd09338
Location:840 → 892

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:781 → 832

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:899 → 950

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:722 → 774

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:1 → 120

Paxillin; Paxillin family
XM_006530204.4 → XP_006530267.1 paxillin isoform X3

See identical proteins and their annotated locations for XP_006530267.1

Conserved Domains (5) summary

cd09338
Location:840 → 892

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:781 → 832

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:899 → 950

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:722 → 774

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:1 → 120

Paxillin; Paxillin family