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    Pex19 peroxisomal biogenesis factor 19 [ Mus musculus (house mouse) ]

    Gene ID: 19298, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pex19provided by MGI
    Official Full Name
    peroxisomal biogenesis factor 19provided by MGI
    Primary source
    MGI:MGI:1334458
    See related
    Ensembl:ENSMUSG00000003464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Px; Pxf
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 42.2), mammary gland adult (RPKM 35.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pex19 in Genome Data Viewer
    Location:
    1 H3; 1 79.54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171954322..171964064)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172126755..172136497)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (174056886..174066628)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nescient helix loop helix 1 Neighboring gene nicastrin Neighboring gene coatomer protein complex subunit alpha Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene DDB1 and CUL4 associated factor 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxisome membrane class-1 targeting sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxisome membrane targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein carrier activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peroxisome membrane biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into peroxisome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein import into peroxisome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxisomal biogenesis factor 19
    Names
    peroxin-19
    peroxisomal farnesylated protein
    peroxisome biogenesis factor 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159525.1NP_001152997.1  peroxisomal biogenesis factor 19 isoform b

      See identical proteins and their annotated locations for NP_001152997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several alternate exons in the coding region, compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AK028449, AK029368
      Consensus CDS
      CCDS48445.1
      UniProtKB/Swiss-Prot
      Q8VCI5
      Related
      ENSMUSP00000106883.4, ENSMUST00000111252.4
      Conserved Domains (1) summary
      pfam04614
      Location:23207
      Pex19; Pex19 protein family
    2. NM_001356513.1NP_001343442.1  peroxisomal biogenesis factor 19 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC074310, AC158930
      Conserved Domains (1) summary
      pfam04614
      Location:74272
      Pex19; Pex19 protein family
    3. NM_001356514.1NP_001343443.1  peroxisomal biogenesis factor 19 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC074310, AC158930
      Conserved Domains (1) summary
      pfam04614
      Location:74284
      Pex19; Pex19 protein family
    4. NM_023041.3NP_075528.3  peroxisomal biogenesis factor 19 isoform a

      See identical proteins and their annotated locations for NP_075528.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK028449, AK029368, AK075576
      Consensus CDS
      CCDS15508.1
      UniProtKB/Swiss-Prot
      Q8VCI5
      Related
      ENSMUSP00000075289.3, ENSMUST00000075895.9
      Conserved Domains (1) summary
      pfam04614
      Location:74299
      Pex19; Pex19 protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171954322..171964064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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