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    Arhgdia Rho GDP dissociation inhibitor (GDI) alpha [ Mus musculus (house mouse) ]

    Gene ID: 192662, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arhgdiaprovided by MGI
    Official Full Name
    Rho GDP dissociation inhibitor (GDI) alphaprovided by MGI
    Primary source
    MGI:MGI:2178103
    See related
    Ensembl:ENSMUSG00000025132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gdi-1; RhoDGI; Rho-GDI; RhoGDI-1; rho GDI 1; 5330430M07Rik; Rho GDI alpha; rho-GDI alpha
    Expression
    Ubiquitous expression in duodenum adult (RPKM 291.0), lung adult (RPKM 246.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arhgdia in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (120577235..120581620, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120438549..120442934, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 27 Neighboring gene prolyl 4-hydroxylase, beta polypeptide Neighboring gene predicted gene, 46304 Neighboring gene Aly/REF export factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC7904, MGC101921

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rac GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rho GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rho GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GDP-dissociation inhibitor 1
    Names
    Rho GDIalpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363425.1NP_001350354.1  rho GDP-dissociation inhibitor 1

      Status: VALIDATED

      Source sequence(s)
      AK077343, AL663030
      Conserved Domains (1) summary
      pfam02115
      Location:11201
      Rho_GDI; RHO protein GDP dissociation inhibitor
    2. NM_133796.8NP_598557.3  rho GDP-dissociation inhibitor 1

      See identical proteins and their annotated locations for NP_598557.3

      Status: VALIDATED

      Source sequence(s)
      AK165241, AL663030, CJ091996
      Consensus CDS
      CCDS25743.1
      UniProtKB/Swiss-Prot
      Q99PT1
      Related
      ENSMUSP00000101803.3, ENSMUST00000106197.9
      Conserved Domains (1) summary
      pfam02115
      Location:11201
      Rho_GDI; RHO protein GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      120577235..120581620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532549.3XP_006532612.1  rho GDP-dissociation inhibitor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q99PT1
      Related
      ENSMUSP00000063714.5, ENSMUST00000067936.5
      Conserved Domains (1) summary
      pfam02115
      Location:11201
      Rho_GDI; RHO protein GDP dissociation inhibitor
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